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Product Details
PA5-106719
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RAB40B(Accession Q12829), corresponding to amino acid residues R234-S278.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2854387
Product Specific Information
Antibody detects endogenous levels of total RAB40B.
Target Information
Rab 40B is a 278 amino acid protein that belongs to the small GTPase superfamily and the Rab family. Rab 40B contains a SOCS box domain that mediates interactions with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. Rab 40B shares similarity with a yeast protein, suggesting a role in regulation of secretory vesicles. The Rab 40B gene is conserved in chimpanzee, cow, mouse, rat, chicken and zebrafish, and maps to human chromosome 17q25.3. It has been suggested that there is a major gene locus on chromosome 17q25.3 for autosomal dominant moyamoya disease (MMD), which is an idiopathic steno-occlusive cerebrovascular disease that represents an important cause of stroke.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTP-binding protein homologous to Saccharomyces cerevisiae SEC4; Protein Rar; RAR SOCS box containing protein; Ras-related protein Rab-40B; sec4; SOCS box-containing protein RAR
Gene Aliases: RAB40B; RAR; SEC4L
UniProt ID: (Human) Q12829, (Mouse) Q8VHP8
Entrez Gene ID: (Human) 10966, (Rat) 303754, (Mouse) 217371
intracellular protein transport
vesicle docking involved in exocytosis
protein secretion
protein ubiquitination
regulation of exocytosis
Rab protein signal transduction
protein localization to plasma membrane
small GTPase mediated signal transduction
symbiont intracellular protein transport in host
protein transport
intracellular signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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