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Product Details
RHES-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 250-317 on RASD2 protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein that is predominantly expressed in the striatal region of the brain. This protein belongs to the RASD subfamily of Ras-related GTP-binding protein superfamily and is thought to play a role in the normal development and function of the brain as mice lacking this gene showed increased anxiety levels and motor coordination deficits. Rhes was identified as TEM2 through analysis of genes whose expression was upregulated in tumor endothelium. Tumor endothelial markers are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTP-binding protein Rhes; Ras homolog enriched in striatum; RASD family, member 2; SE6C; Tumor endothelial marker 2
Gene Aliases: 4930526B11Rik; AU045414; MGC:4834; RASD2; Rhes; TEM-2; TEM2
UniProt ID: (Human) Q96D21, (Rat) P63033, (Mouse) Q9WVD3
Entrez Gene ID: (Human) 23551, (Rat) 171099, (Mouse) 75141
synaptic transmission, dopaminergic
small GTPase mediated signal transduction
locomotory behavior
negative regulation of protein ubiquitination
positive regulation of protein sumoylation
regulation of cAMP-mediated signaling
positive regulation of protein kinase B signaling
signal transduction
behavior
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