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Proteintech

RENALASE Polyclonal Antibody

11 References

View all (13) Renalase antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (8)

Application

RENALASE Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

RENALASE Antibody (15003-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol) fixed HEK-293 cells using 15003-1-AP (RENALASE antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

RENALASE Antibody in Immunohistochemistry (Paraffin) (IHC (P))

RENALASE Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

RENALASE Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15003-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:100

Immunocytochemistry (ICC/IF)

1:50-1:500

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RENALASE Fusion Protein Ag13061 (1-342 aa encoded by BC005364)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to RNLS.

Immunogen sequence: MAQVLIVGA GMTGSLCAAL LRRQTSGPLY LAVWDKADDS GGRMTTACSP HNPQCTADLG AQYITCTPHY AKKHQRFYDE LLAYGVLRPL SSPIEGMVMK EGDCNFVAPQ GISSIIKHYL KESGAEVYFR HRVTQINLRD DKWEVSKQTG SPEQFDLIVL TMPVPEILQL QGDITTLISE CQRQQLEAVS YSSRYALGLF YEAGTKIDVP WAGQYITSNP CIRFVSIDNK KRNIESSEIG PSLVIHTTVP FGVTYLEHSI EDVQELVFQQ LENILPGLPQ PIATKCQKWR HSQVTNAAAN CPGQMTLHHK PFLACGGDGF TQSNFDGCIT SALCVLEALK NYI (1-342 aa encoded by BC005364)

Target Information

Renalase is a flavoprotein enzyme encoded by the RNLS gene, primarily expressed in the kidneys and heart where it plays a critical role in metabolizing catecholamines and catecholamine-like substances. It utilizes nicotinamide adenine dinucleotide (NADH) as a cofactor and operates through a superoxide-dependent mechanism, which is distinct from monoamine oxidase pathways. Renalase is considered a novel renal hormone that influences blood pressure and cardiac function by regulating circulating catecholamines. Its genetic variants have been associated with essential hypertension, highlighting its importance in cardiovascular health. In diabetic nephropathy, renalase exhibits protective effects, as demonstrated in genetically modified mouse models. These models have shown that renalase overexpression can mitigate renal damage, suggesting therapeutic potential. Renalase's expression is highest in the proximal tubules of the kidneys, which are densely innervated by sympathetic nerves, underscoring the connection between renalase and sympathetic nervous system activity. This enzyme's discovery has enriched our understanding of renal hormone regulation and its implications in diseases such as chronic kidney disease (CKD) and end-stage renal disease (ESRD).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Aerobic Exercise Training Improves Renal Injury in Spontaneously Hypertensive Rats by Increasing Renalase Expression in Medulla.

Frontiers in cardiovascular medicine

Luo M,Cao S,Lv D,He L,He Z,Li L,Li Y,Luo S,Chang Q

Fri Jul 29 00:00:00 UTC 2022

Aerobic Exercise Training Improves Renal Injury in Spontaneously Hypertensive Rats by Increasing Renalase Expression in Medulla.

Frontiers in cardiovascular medicine

Luo M,Cao S,Lv D,He L,He Z,Li L,Li Y,Luo S,Chang Q

Fri Jul 29 00:00:00 UTC 2022

Renalase is localized to the small intestine crypt and expressed upon the activation of NF-κB p65 in mice model of fasting-induced oxidative stress.

Life sciences

Aoki K,Yanazawa K,Tokinoya K,Sugasawa T,Suzuki T,Yoshida Y,Nakano T,Omi N,Kawakami Y,Takekoshi K

Mon Feb 15 00:00:00 UTC 2021

Renalase is localized to the small intestine crypt and expressed upon the activation of NF-κB p65 in mice model of fasting-induced oxidative stress.

Life sciences

Aoki K,Yanazawa K,Tokinoya K,Sugasawa T,Suzuki T,Yoshida Y,Nakano T,Omi N,Kawakami Y,Takekoshi K

Mon Feb 15 00:00:00 UTC 2021

Plasma and urine renalase levels and activity during the recovery of renal function in kidney transplant recipients.

Experimental biology and medicine (Maywood, N.J.)

Quelhas-Santos J,Soares-Silva I,Fernandes-Cerqueira C,Simões-Silva L,Ferreira I,Carvalho C,Coentrão L,Vaz R,Sampaio-Maia B,Pestana M

Tue Apr 01 00:00:00 UTC 2014

Plasma and urine renalase levels and activity during the recovery of renal function in kidney transplant recipients.

Experimental biology and medicine (Maywood, N.J.)

Quelhas-Santos J,Soares-Silva I,Fernandes-Cerqueira C,Simões-Silva L,Ferreira I,Carvalho C,Coentrão L,Vaz R,Sampaio-Maia B,Pestana M

Tue Apr 01 00:00:00 UTC 2014

Renalase deficiency aggravates ischemic myocardial damage.

Kidney international

Wu Y,Xu J,Velazquez H,Wang P,Li G,Liu D,Sampaio-Maia B,Quelhas-Santos J,Russell K,Russell R,Flavell RA,Pestana M,Giordano F,Desir GV

Fri Apr 01 00:00:00 UTC 2011

Renalase deficiency aggravates ischemic myocardial damage.

Kidney international

Wu Y,Xu J,Velazquez H,Wang P,Li G,Liu D,Sampaio-Maia B,Quelhas-Santos J,Russell K,Russell R,Flavell RA,Pestana M,Giordano F,Desir GV

Fri Apr 01 00:00:00 UTC 2011

Saturday, june 26, 2010: poster session 1.

NDT plus

No authors listed

Tue Jun 01 00:00:00 UTC 2010

Catecholamines regulate the activity, secretion, and synthesis of renalase.

Circulation

Li G,Xu J,Wang P,Velazquez H,Li Y,Wu Y,Desir GV

Tue Mar 11 00:00:00 UTC 2008

Catecholamines regulate the activity, secretion, and synthesis of renalase.

Circulation

Li G,Xu J,Wang P,Velazquez H,Li Y,Wu Y,Desir GV

Tue Mar 11 00:00:00 UTC 2008

Catecholamines regulate the activity, secretion, and synthesis of renalase.

Circulation

Li G,Xu J,Wang P,Velazquez H,Li Y,Wu Y,Desir GV

Tue Mar 11 00:00:00 UTC 2008

Catecholamines regulate the activity, secretion, and synthesis of renalase.

Circulation

Li G,Xu J,Wang P,Velazquez H,Li Y,Wu Y,Desir GV

Tue Mar 11 00:00:00 UTC 2008

Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure.

The Journal of clinical investigation

Xu J,Li G,Wang P,Velazquez H,Yao X,Li Y,Wu Y,Peixoto A,Crowley S,Desir GV

Sun May 01 00:00:00 UTC 2005

Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure.

The Journal of clinical investigation

Xu J,Li G,Wang P,Velazquez H,Yao X,Li Y,Wu Y,Peixoto A,Crowley S,Desir GV

Sun May 01 00:00:00 UTC 2005

Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure.

The Journal of clinical investigation

Xu J,Li G,Wang P,Velazquez H,Yao X,Li Y,Wu Y,Peixoto A,Crowley S,Desir GV

Sun May 01 00:00:00 UTC 2005

Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure.

The Journal of clinical investigation

Xu J,Li G,Wang P,Velazquez H,Yao X,Li Y,Wu Y,Peixoto A,Crowley S,Desir GV

Sun May 01 00:00:00 UTC 2005

Bioinformatics

Protein Aliases: alpha-NAD(P)H oxidase/anomerase; FLJ11218; HGNC:25641; MAO-C; mMAO-C; Monoamine oxidase-C; Renalase; renalase, FAD-dependent amine oxidase; rnls

Gene Aliases: 6530404N21Rik; AI452315; AW060440; C10orf59; RENALASE; RGD1309804; RNLS

UniProt ID: (Human) Q9NUP8, (Rat) Q5U2W9

Entrez Gene ID: (Human) 55328, (Rat) 361751, (Mouse) 67795

Function(s)

Process(es)

response to ischemia regulation of systemic arterial blood pressure cardiac left ventricle morphogenesis epinephrine metabolic process norepinephrine metabolic process dopamine metabolic process phosphate ion homeostasis oxidation-reduction process heart contraction response to catecholamine response to epinephrine response to norepinephrine response to salt

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RENALASE Polyclonal Antibody

RENALASE Antibody (15003-1-AP) in ICC/IF

Product Details

15003-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Function(s)

Process(es)

Performance Guarantee

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