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Application
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RFX3 Antibody (PA5-99703) in WB
Western blot analysis of RFX3 in HepG2 cell lysate. Samples were incubated with RFX3 polyclonal antibody (Product # PA5-99703).
Product Details
PA5-99703
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RFX3(Accession P48380), corresponding to amino acid residues G647-T697.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2818636
Product Specific Information
Antibody detects endogenous levels of total RFX3.
Target Information
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding different isoforms have been described for this gene, and at least one of the variants utilizes alternative polyadenylation signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bA32F11.1; DNA binding protein RFX3; Regulatory factor X 3; regulatory factor X, 3 (influences HLA class II expression); Transcription factor RFX3
Gene Aliases: C230093O12Rik; MRFX3; RFX3
UniProt ID: (Human) P48380, (Mouse) P48381
Entrez Gene ID: (Human) 5991, (Mouse) 19726
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription regulatory region DNA binding
sequence-specific DNA binding
winged helix/forkhead transcription factor
type B pancreatic cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
endocrine pancreas development
cilium assembly
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell maturation
regulation of insulin secretion
cilium-dependent cell motility
epithelial cilium movement involved in determination of left/right asymmetry
type B pancreatic cell maturation
positive regulation of type B pancreatic cell development
multicellular organism development
determination of left/right symmetry
cell differentiation
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