Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and human.
Specificity of this antibody: RIM2.
Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: non-small cell lung cancer RimL3a protein; non-small cell lung cancer RimL3c protein; nuclear protein; Rab-3-interacting molecule 2; Rab-3-interacting protein 2; Rab-3-interacting protein 3; Rab3 interacting protein 1; Rab3 interacting protein 2; RAB3 interacting protein 3; rab3-interacting molecule 2; Rab3-interacting protein; rab3-interacting protein 2; Regulating synaptic membrane exocytosis protein 2; RIM 2; RIM2 (CT); synaptic exocytosis regulator 2; synaptotagmin 3, related sequence
Gene Aliases: 2810036I15Rik; AW048769; KIAA0751; mKIAA0751; Nim2; OBOE; Rab3ip2; RAB3IP3; RIM2; Rim2(+40A); Rim2(+44A); Rim2(+4A); RIMS2; Serg2; Syt3-rs
UniProt ID: (Human) Q9UQ26, (Rat) Q9JIS1, (Mouse) Q9EQZ7
Entrez Gene ID: (Human) 9699, (Rat) 116839, (Mouse) 116838
Molecular Function:
membrane traffic protein
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