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Immunogen sequence: ASFSDSEDES CVPLLRKESI QLRDLDSALL AEVKDVLIPH ERVVTHSDRV IGKGHFGVVY HGEYIDQAQN RIQCAIKSLS RITEMQQVEA FLREGLLMRG LNHPNVLALI GIMLPPEGLP HVLLPYMCHG DLLQFIRSPQ RNPTVKDLIS FGLQVARGME YLAEQKFVHR DLAARNCMLD ESFTVKVADF GLARDILDRE YYSVQQHRHA RLPVKWMALE SLQTYRFTTK SDVWSFGVLL WELLTRGAPP YRHIDPFDLT HFLAQGRRLP QPEYCPDSLY QVMQQCWEAD PAVRP
MST1R (RON) is a receptor tyrosine kinase involved in cell proliferation and motility. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. MST1R/Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uteru.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: c-met-related tyrosine kinase; CD136; CDw136; Macrophage-stimulating protein receptor; MSP receptor; MST1R variant RON30; MST1R variant RON62; p185-Ron; Protein-tyrosine kinase 8; PTK8 protein tyrosine kinase 8; RON variant E2E3
Gene Aliases: CD136; CDw136; MST1R; PTK8; RON
UniProt ID: (Human) Q04912
Entrez Gene ID: (Human) 4486
Molecular Function:
transmembrane signal receptor
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