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Immunogen sequence: KYILPLKTPG RADDPHFRPL PTEPAEREPR SSETSRIYTW ARGRVVSSDS DSDSDLSSSS LEDRLPSTGV RDRKGDKPWK ESGGSVEAPR MGFTHPPGHL SGCQSSLASG ETGTGSADPP GGPRPGLTRR APVKDTPGRA PAADAAPAGP SSCLG; Positive Samples: BT-474, 22Rv1, SW620, NCI-H460; Cellular Location: Cytoplasm, Cytoplasmic vesicle, secretory vesicle membrane
The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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Protein Aliases: No C2 domains protein; Rab effector Noc2; Rabphilin-3A-like protein
Gene Aliases: Gm1753; NOC2; RPH3AL
UniProt ID: (Human) Q9UNE2, (Mouse) Q768S4
Entrez Gene ID: (Human) 9501, (Mouse) 380714
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