Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: QKQGPPCSD SEEEVERKKK CHKQALVGSD SAEDEKRKRK CQKHAPINSA QHLDNVDQTG PKAWKGSTTN DPPKQSPGST SPKPPHTLSR KQWRNRQKNK RRCKNKFQPP QVPDQAPAEA PTEKTEVSPV PRTDSHEARA GALRARMAQR LDGARFRYLN EQLYSGPSSA AQRLFQEDPE AFLLYHRGFQ SQVKKWPLQP VDRIARDLRQ RPASLVVADF GCGDCRLASS IRNPVHCFDL ASLDPRVTVC DMAQVPLEDE SVDVAVFCLS LMGTNIRDFL EEANRVLKPG GLLKVAEVSS RFEDVRTFLR AVTKLGFKIV SKDLTNSHFF LFDFQKTGPP LVGPKAQLSG LQLQPCLYKR R (97-456 aa encoded by BC001071)
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cerebral protein 1; Cerebral protein 1 homolog; HUCE1; hucep1; Nucleomethylin; Ribosomal RNA-processing protein 8; RRP-8; RRP8 methyltransferase homolog
Gene Aliases: 1500003O22Rik; 2900001K19Rik; AW538116; hucep-1; KIAA0409; NML; RGD1308302; RRP8
UniProt ID: (Human) O43159, (Mouse) Q9DB85, (Rat) Q5U4F0
Entrez Gene ID: (Human) 23378, (Mouse) 101867, (Rat) 308911
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