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            • Primary Antibodies ›
            • RUVBL2 Antibodies

            OriGene

            RUVBL2 Monoclonal Antibody (OTI1H10), TrueMAB™

            View all (29) RUVBL2 antibodies
            Datasheet
            Protocols
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            Datasheet
            Protocols
            Questions & Answers

            Cite RUVBL2 Monoclonal Antibody (OTI1H10), TrueMAB™

            • Antibody Testing Data (13)
            Application
            RUVBL2 Antibody in Immunocytochemistry (ICC/IF)
            Group 53 Created with Sketch.

            FIGURE: 1 / 13

            RUVBL2 Antibody (CF504284) in ICC/IF

            Anti-RUVBL2 mouse monoclonal antibody (TA504284) Immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RUVBL2(RC200933).
            View Product

            RUVBL2 Antibody in Immunocytochemistry (ICC/IF)
            RUVBL2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            RUVBL2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            RUVBL2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            RUVBL2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            RUVBL2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            RUVBL2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            RUVBL2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            RUVBL2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            RUVBL2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            RUVBL2 Antibody in Western Blot (WB)
            RUVBL2 Antibody in Flow Cytometry (Flow)
            RUVBL2 Antibody in Flow Cytometry (Flow)

            Product Details

            CF504284

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1:2,000
            -

            Immunohistochemistry (Paraffin) (IHC (P))

            1:150
            -

            Immunocytochemistry (ICC/IF)

            1:100
            -

            Flow Cytometry (Flow)

            1:100
            -
            Product Specifications

            Species Reactivity

            Human

            Host/Isotype

            Mouse / IgG1

            Class

            Monoclonal

            Type

            Antibody

            Clone

            OTI1H10

            Immunogen

            Human recombinant protein fragment corresponding to amino acids 113-370 of human RUVBL2 produced in E.coli.
            View immunogen

            Conjugate

            Unconjugated

            Form

            Lyophilized

            Concentration

            1 mg/mL

            Purification

            Affinity chromatography

            Storage buffer

            PBS, pH 7.3, with 8% trehalose

            Contains

            no preservative

            Storage conditions

            -20°C, Avoid Freeze/Thaw Cycles

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            Product Specific Information

            For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

            Target Information

            Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL2 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            References (0)

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            Cite this product

            Bioinformatics

            Protein Aliases: 48 kDa TATA box-binding protein-interacting protein; 48 kDa TBP-interacting protein; 51 kDa erythrocyte cytosolic protein; ECP-51; erythrocyte cytosolic protein, 51-KD; INO80 complex subunit J; Repressing pontin 52; Reptin 52; reptin52 protein; RuvB (E coli homolog)-like 2; RuvB-like 2; RUVBL2 protein; TAP54-beta; TIP49b; TIP60-associated protein 54-beta

            View more View less

            Gene Aliases: CGI-46; ECP-51; ECP51; INO80J; REPTIN; RUVBL2; RVB2; TAP54-beta; TIH2; TIP48; TIP49B

            View more View less

            UniProt ID: (Human) Q9Y230

            View more View less

            Entrez Gene ID: (Human) 10856

            View more View less

            Function(s)

            RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding TFIID-class transcription factor binding DNA helicase activity ATP-dependent DNA helicase activity protein binding ATP binding ATPase activity chromatin DNA binding identical protein binding protein homodimerization activity ATP-dependent 5'-3' DNA helicase activity ADP binding unfolded protein binding ATPase binding

            Process(es)

            box C/D snoRNP assembly DNA repair DNA recombination chromatin remodeling transcription, DNA-templated protein folding DNA duplex unwinding cellular response to UV positive regulation of histone acetylation regulation of growth histone H4 acetylation histone H2A acetylation positive regulation of transcription from RNA polymerase II promoter establishment of protein localization to chromatin cellular response to estradiol stimulus transcriptional activation by promoter-enhancer looping negative regulation of estrogen receptor binding positive regulation of telomerase RNA localization to Cajal body
            It has to be done as per old AB suggested Products section.
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            Performance Guarantee

            If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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