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Reelin Antibody (PA5-68310) in WB
Western blot was performed using Anti-Reelin Polyclonal Antibody(Product # PA5-68310) and a 400kDa band corresponding to Reelin was observed across in cerebellum when compared to other tissues. Tissue extracts (30 µg lysate) of Mouse Cerebellum (Lane 1), Rat Cerebellum (Lane 2), Mouse Liver (Lane 3), Rat Liver (Lane 4), Mouse Skeletal Muscle (Lane 5), Rat Skeletal Muscle (Lane 6) were electrophoresed using NuPAGE™ 3-8% Tris-Acetate Protein Gel (Product # EA0378BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Pr... View More
Product Details
PA5-68310
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human Reelin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2691967
Product Specific Information
Predicted to react with Human and Rat samples.
Target Information
Reelin in an extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Reelin
Gene Aliases: ETL7; LIS2; PRO1598; Reelen; reeler; RELN; RL
UniProt ID: (Human) P78509, (Rat) P58751
Entrez Gene ID: (Human) 5649, (Rat) 24718
cell morphogenesis involved in differentiation
neuron migration
proteolysis
cell adhesion
axon guidance
central nervous system development
brain development
long-term memory
associative learning
glial cell differentiation
positive regulation of neuron projection development
positive regulation of phosphatidylinositol 3-kinase signaling
dendrite development
peptidyl-tyrosine phosphorylation
spinal cord patterning
ventral spinal cord development
hippocampus development
cerebral cortex tangential migration
layer formation in cerebral cortex
positive regulation of TOR signaling
positive regulation of CREB transcription factor activity
reelin-mediated signaling pathway
positive regulation of protein kinase activity
response to pain
positive regulation of peptidyl-tyrosine phosphorylation
regulation of behavior
modulation of synaptic transmission
positive regulation of small GTPase mediated signal transduction
positive regulation of synaptic transmission, glutamatergic
long-term synaptic potentiation
positive regulation of dendritic spine morphogenesis
positive regulation of protein tyrosine kinase activity
positive regulation of synapse maturation
NMDA glutamate receptor clustering
postsynaptic density protein 95 clustering
receptor localization to synapse
lateral motor column neuron migration
positive regulation of long-term synaptic potentiation
positive regulation of lateral motor column neuron migration
regulation of N-methyl-D-aspartate selective glutamate receptor activity
positive regulation of excitatory postsynaptic potential
positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
midgut development
memory
locomotory behavior
response to mechanical stimulus
response to toxic substance
response to hormone
response to lithium ion
regulation of gene expression
response to organic cyclic compound
cell migration
response to insecticide
dentate gyrus development
orbitofrontal cortex development
hypothalamus development
cerebral cortex development
forebrain development
response to progesterone
social behavior
protein localization to synapse
thyroid hormone metabolic process
response to drug
response to amino acid
response to ethanol
response to axon injury
response to corticosterone
response to electrical stimulus
response to fatty acid
cellular response to dexamethasone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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