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NeoBiotechnologies
Renalase (Renal Cell Marker) Monoclonal Antibody (RNLS/1940)
Product Details
55328-MSM2-P0
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
RNLS/1940
Immunogen
Recombinant human RNLS protein fragment (around aa 34-235).
Conjugate
Unconjugated
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Renalase is a flavoprotein enzyme encoded by the RNLS gene, primarily expressed in the kidneys and heart where it plays a critical role in metabolizing catecholamines and catecholamine-like substances. It utilizes nicotinamide adenine dinucleotide (NADH) as a cofactor and operates through a superoxide-dependent mechanism, which is distinct from monoamine oxidase pathways. Renalase is considered a novel renal hormone that influences blood pressure and cardiac function by regulating circulating catecholamines. Its genetic variants have been associated with essential hypertension, highlighting its importance in cardiovascular health. In diabetic nephropathy, renalase exhibits protective effects, as demonstrated in genetically modified mouse models. These models have shown that renalase overexpression can mitigate renal damage, suggesting therapeutic potential. Renalase's expression is highest in the proximal tubules of the kidneys, which are densely innervated by sympathetic nerves, underscoring the connection between renalase and sympathetic nervous system activity. This enzyme's discovery has enriched our understanding of renal hormone regulation and its implications in diseases such as chronic kidney disease (CKD) and end-stage renal disease (ESRD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-NAD(P)H oxidase/anomerase; FLJ11218; HGNC:25641; MAO-C; Monoamine oxidase-C; Renalase; renalase, FAD-dependent amine oxidase
Gene Aliases: C10orf59; RENALASE; RNLS
UniProt ID: (Human) Q9NUP8
Entrez Gene ID: (Human) 55328
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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