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The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene.
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蛋白别名: 2310075M17Rik; GTBPB; GTP-binding protein B; GTP-binding protein SAR1b; GTP-binding protein Sara; SAR1 gene homolog B; SAR1 homolog B; SAR1a gene homolog 2; SAR1b gene homolog; secretion associated, Ras related GTPase 1B; Secretion-associated Ras-related GTPase 1B; Small COPII coat GTPase SAR1B; small GTP binding protein
基因别名: 2310075M17Rik; 2900019I22Rik; ANDD; CMRD; GTBPB; SAR1B; SARA1B; SARA2; SARB
UniProt ID: (Human) Q9Y6B6, (Pig) Q4ZJK0, (Rat) Q5HZY2, (Mouse) Q9CQC9
Entrez Gene ID: (Rabbit) 100340384, (Human) 51128, (Pig) 494017, (Rat) 287276, (Mouse) 66397