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            • Primary Antibodies ›
            • SCK Antibodies

            Invitrogen

            SCK Polyclonal Antibody

            View all (6) SCK antibodies
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            Protocols
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            Datasheet
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            Cite SCK Polyclonal Antibody

            • Antibody Testing Data (2)
            Application
            SCK Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            Group 53 Created with Sketch.

            FIGURE: 1 / 2

            SCK Antibody (PA5-148340) in IHC (P)

            Immunohistochemistry analysis of SCK in formalin-fixed paraffin embedded human stomach sections. Samples were incubated with SCK polyclonal antibody (Product # PA5-148340) using a dilution of 1:100.
            View Product

            SCK Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            SCK Antibody in Immunohistochemistry (Paraffin) (IHC (P))

            Product Details

            PA5-148340

            Applications
            Tested Dilution
            Publications

            Immunohistochemistry (Paraffin) (IHC (P))

            1:50-1:200
            -
            Product Specifications

            Species Reactivity

            Human

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            E. coli-derived Human SHC2 fragment

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            100 µg/mL

            Purification

            Antigen affinity chromatography, Protein A

            Storage buffer

            PBS, pH 7

            Contains

            0.03% ProClin 300

            Storage conditions

            Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_3247509

            Target Information

            Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events. Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain. Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary. In vascular endothelial cells, Sck participates in VEGF-induced signal transduction. Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            References (0)

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            Cite this product

            Bioinformatics

            Protein Aliases: neuronal Shc adaptor homolog; Protein Sck; SH2 domain protein C2; SHC (Src homology 2 domain containing) transforming protein 2; SHC-transforming protein 2; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2

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            Gene Aliases: SCK; SHC2; SHCB; SLI

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            UniProt ID: (Human) P98077

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            Entrez Gene ID: (Human) 25759

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            Function(s)

            Ras guanyl-nucleotide exchange factor activity protein binding receptor tyrosine kinase binding scaffold/adaptor protein

            Process(es)

            MAPK cascade activation of MAPK activity transmembrane receptor protein tyrosine kinase signaling pathway Ras protein signal transduction positive regulation of GTPase activity vascular endothelial growth factor receptor signaling pathway
            It has to be done as per old AB suggested Products section.
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