Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: RNKCLQWPPD NSSFEINITS FFNNSLDGNG TTFNRTVSIF NWDEYIEDKS HFYFLEGQND ALLCGNSSDA GQCPEGYICV KAGRNPNYGY TSFDTFSWAF LSLFRLMTQD FWENLYQLTL RAAGKTY; Positive Samples: U-87MG, K-562; Cellular Location: Cell membrane, Multi-pass membrane protein
Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are more abundant along axons. The beta1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.
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Protein Aliases: Brain Type II; HBSC II; Sodium channel protein brain II subunit alpha; Sodium channel protein type 2 subunit alpha; Sodium channel protein type II subunit alpha; sodium channel protein, brain type 2 alpha subunit; sodium channel, voltage gated, type II alpha subunit; sodium channel, voltage-gated, type II, alpha 1 polypeptide; sodium channel, voltage-gated, type II, alpha 2 polypeptide; sodium channel, voltage-gated, type II, alpha subunit; voltage-gated sodium channel subtype II; Voltage-gated sodium channel subunit alpha Nav1.2; voltage-gated sodium channel type II alpha subunit
Gene Aliases: BFIC3; BFIS3; BFNIS; EIEE11; HBA; HBSCI; HBSCII; Na(v)1.2; NAC2; Nav1.2; SCN2A; SCN2A1; SCN2A2
UniProt ID: (Human) Q99250
Entrez Gene ID: (Human) 6326
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