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            • Primary Antibodies ›
            • SCN4A Antibodies

            Alomone Labs, LTD

            SCN4A (NaV1.4) Polyclonal Antibody

            View all (9) SCN4A antibodies
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            Cite SCN4A (NaV1.4) Polyclonal Antibody

            • Antibody Testing Data (1)
            Application
            SCN4A (NaV1.4) Antibody in Western Blot (WB)
            Group 53 Created with Sketch.

            FIGURE: 1 / 1

            SCN4A (NaV1.4) Antibody (ASC-020-200UL) in WB

            Western blot analysis of rat skeletal muscle lysate: - 1. Anti-SCN4A (NaV1.4) Antibody (#ASC-020), (1:200).2. Anti-SCN4A (NaV1.4) Antibody , preincubated with SCN4A/Nav1.4 Blocking Peptide (#BLP-SC020).
            View Product

            SCN4A (NaV1.4) Antibody in Western Blot (WB)

            Product Details

            ASC-020-200UL

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1:200
            -
            Product Specifications

            Species Reactivity

            Human, Mouse, Rat

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            EDKELKDNHILNHVG(C), corresponding to amino acid residues 877-891 of rat NaV1.4, Intracellular loop between domains II and III
            View immunogen

            Conjugate

            Unconjugated

            Form

            Lyophilized

            Concentration

            0.8 mg/mL

            Purification

            Antigen affinity chromatography

            Storage buffer

            PBS, pH 7.4, with 1% BSA

            Contains

            0.05% sodium azide

            Storage conditions

            -20°C, Avoid Freeze/Thaw Cycles

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            Product Specific Information

            Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

            Target Information

            Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The three glycoproteins that comprise the voltagegated sodium channel proteins include a pore-forming alpha subunit, a noncovalently associated beta1 subunit and a disulfide-linked beta2 subunit. The two beta subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are more abundant along axons. The beta1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            References (0)

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            Cite this product

            Bioinformatics

            Protein Aliases: CTC-264K15.6; hNaN; KIAA1356; MED; Mu-1; NAC1; NAC2; NAC3; Nav1.1; Nav1.2; Nav1.3; Nav1.5; Nav1.6; Nav1.7; Nav1.8; Nav1.9; NENA; SCN1; SCN10A; SCN11A; SCN12A; SCN1A; SCN2A; SCN2A1; SCN2A2; SCN3A; SCN5A; SCN8A; SCN9A; skeletal muscle sodium channel alpha subunit; skeletal muscle voltage-dependent sodium channel type IV alpha subunit; SkM1; SNS2; sodium channel alpha-subunit; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type 4 subunit alpha; Sodium channel protein type IV subunit alpha; sodium channel voltage-gated type 4 alpha polypeptide; Sodium channel voltage-gated type IV alpha polypeptide; sodium channel, voltage gated, type IV alpha subunit; sodium channel, voltage-gated, type 4, alpha polypeptide; sodium channel, voltage-gated, type 4, alpha subunit; sodium channel, voltage-gated, type IV, alpha polypeptide; sodium channel, voltage-gated, type IV, alpha subunit; Voltage-gated sodium channel subunit alpha Nav1.4

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            Gene Aliases: CMS16; HOKPP2; HYKPP; HYPP; mH2; microI; Na(V)1.4; NAC1A; Nav1.4; NCHVS; SCN4A; SkM1

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            UniProt ID: (Human) P35499, (Mouse) Q9ER60, (Rat) P15390

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            Entrez Gene ID: (Human) 6329, (Mouse) 110880, (Rat) 25722

            View more View less

            Function(s)

            voltage-gated sodium channel activity ion channel activity voltage-gated ion channel activity sodium channel activity voltage-gated ion channel

            Process(es)

            potassium ion transport sodium ion transport muscle contraction choline transport neuronal action potential regulation of ion transmembrane transport sodium ion transmembrane transport regulation of postsynaptic membrane potential membrane depolarization during action potential transport ion transport cation transport transmembrane transport
            It has to be done as per old AB suggested Products section.
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            If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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