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Immunogen sequence: TIQDLILDL RVRCVMATLQ HTAEEIKRLA EKEDWIVDNE GLTSLPCQFE QCIVCSLQSL KGVLECKPGE ASVFQQPKTQ EEVCQLSINI MQVFIYCLEQ LSTKPDADID TTHLSVDVSS PDLFGSIHED FSLTSEQRLL IVLSNCCYLE RHTFLNIAEH FEKHNFQGIE KITQVSMASL KELDQRLFEN YIELKADPIV GSLEPGIYAG YFDWKDCLPP TGVRNYLKEA LVNIIAVHAE VFTISKELVP RVLSKVIEAV SEELSRLMQC VSSFSKNGAL QARLEICALR DTVAVYLTPE SKSSFKQALE ALPQLSSGAD KKLLEELLNK FKSSMHLQLT CFQAASSTMM KT (456-806 aa encoded by BC016918)
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Exocyst complex component 2; Exocyst complex component Sec5; rSec5; SEC5 homolog; SEC5-like 1
Gene Aliases: 2410030I24Rik; AI648199; EXOC2; Rsec5; SEC5; SEC5L1; Sec5p
UniProt ID: (Human) Q96KP1, (Mouse) Q9D4H1, (Rat) O54921
Entrez Gene ID: (Pig) 100520314, (Human) 55770, (Mouse) 66482, (Rat) 171455
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