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Search Thermo Fisher Scientific
Immunogen sequence: MYSNVIGTVT SGKRKVYLLS LLLIGFWDCV TCHGSPVDIC TAEPRDIPMN PMCIYRSPEK KATEDEGSEQ KIPEATNRRV WELSKANSRF ATTFYQHLAD SKNDNDNIFL SPLSISTAFA MTKLGACNDT LQQLMEVFKF DTISEKTSDQ IHFFFAKLNC RLYRKANKSS KLVSANRLFG DKSLTFNDLY VSDAFHKAFL EVNEEGSEAA ASTAVVIAGR SLNPNRVTFK ANRPFLVFIR EVPLNTIIFM GRVANPCVK
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.
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Protein Aliases: Antithrombin 3; Antithrombin-III; ATIII; MGC22579; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; Serpin C1; serpin peptidase inhibitor clade C member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1
Gene Aliases: AT3; AT3D; ATIII; PRO0309; SERPINC1; THPH7
UniProt ID: (Human) P01008
Entrez Gene ID: (Human) 462
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