Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: MDFQHRPGGK TGSGGVASSS ESNRDRRERL RQLALETIDI NKDPYFMKNH LGSYECKLCL TLHNNEGSYL AHTQGKKHQT NLARRAAKEA KEAPAQPAPE KVKVEVKKFV KIGRPGYKVT KQRDSEMGQQ SLLFQIDYPE IAEGIMPRHR FMSAYEQRIE PPDRRWQYLL MAAEPYETIA FKVPSREIDK AEGKFWTHWN RETKQFFLQF HFKMEKPPAP; Positive Samples: Mouse testis, Rat testis; Cellular Location: Nucleus
This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein.
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Protein Aliases: SAP 62; SF3a66; spliceosomal protein gene 62; spliceosome-associated protein 62; Splicing factor 3A subunit 2; splicing factor 3a, subunit 2, 66kD; splicing factor 3a, subunit 2, 66kDa
Gene Aliases: 66kDa; AW047242; PRP11; Sap62; Sf3a2; SFA66
UniProt ID: (Rat) Q6AXT8
Entrez Gene ID: (Mouse) 20222, (Rat) 299620
Molecular Function:
RNA splicing factor
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