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Product Details
PA5-110361
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 30-317 of human SFRP5 (NP_003006.2).
Conjugate
Form
Liquid
Concentration
1.85 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2855772
Product Specific Information
Immunogen sequence: EEYDYYGWQA EPLHGRSYSK PPQCLDIPAD LPLCHTVGYK RMRLPNLLEH ESLAEVKQQA SSWLPLLAKR CHSDTQVFLC SLFAPVCLDR PIYPCRSLCE AVRAGCAPLM EAYGFPWPEM LHCHKFPLDN DLCIAVQFGH LPATAPPVTK ICAQCEMEHS ADGLMEQMCS SDFVVKMRIK EIKIENGDRK LIGAQKKKKL LKPGPLKRKD TKRLVLHMKN GAGCPCPQLD SLAGSFLVMG RKVDGQLLLM AVYRWDKKNK EMKFAVKFMF SYPCSLYYPF FYGAAEPH
Target Information
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Frizzled-related protein 1b; FRP-1b; SARP-3; secreted apoptosis related protein 3; Secreted apoptosis-related protein 3; Secreted frizzled-related protein 5; secreted frizzled-related sequence protein 5; sFRP-5
Gene Aliases: AI605071; FRP1B; SARP3; SFRP5
UniProt ID: (Human) Q5T4F7, (Mouse) Q9WU66
Entrez Gene ID: (Human) 6425, (Mouse) 54612, (Rat) 309377
apoptotic process
establishment or maintenance of cell polarity
signal transduction
G-protein coupled receptor signaling pathway
multicellular organism development
visual perception
negative regulation of cell proliferation
anatomical structure morphogenesis
cell differentiation
negative regulation of Wnt signaling pathway
negative regulation of catenin import into nucleus
non-canonical Wnt signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of protein kinase B signaling
negative regulation of canonical Wnt signaling pathway
negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis
Wnt signaling pathway
post-anal tail morphogenesis
negative regulation of JUN kinase activity
digestive tract morphogenesis
convergent extension involved in axis elongation
canonical Wnt signaling pathway
regulation of establishment of planar polarity
planar cell polarity pathway involved in neural tube closure
negative regulation of planar cell polarity pathway involved in axis elongation
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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