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Sodium-dependent glucose transporter. Has a Na+ to glucose coupling ratio of 1:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.
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Protein Aliases: low affinity Na-dependent glucose transporter (SGLT2); low affinity sodium-dependent glucose cotransporter; Low affinity sodium-glucose cotransporter; Na(+)/glucose cotransporter 2; SGLT-2; Sodium/glucose cotransporter 2; solute carrier family 5 (sodium/glucose cotransporter), member 2; solute carrier family 5 (sodium/glucose transporter), member 2; Solute carrier family 5 member 2
Gene Aliases: SGLT2; SLC5A2
UniProt ID: (Human) P31639, (Mouse) Q923I7, (Rat) P53792
Entrez Gene ID: (Human) 6524, (Mouse) 246787, (Rat) 64522
Molecular Function:
secondary carrier transporter
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