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Possible role in regulating endocytosis of the transferrin receptor at the plasma membrane. Alternatively, may function as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: SH3 domain-binding protein 4-A; SH3-domain binding protein 4; src homology 3 binding protein 4
Gene Aliases: sh3bp4; sh3bp4a; si:dkey-110p14.1
UniProt ID: (Zebrafish) Q1LVQ2
Entrez Gene ID: (Zebrafish) 403082
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