Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: DYNQLALTAR LFRPRLIIAG TSAYARLIDY ARMREVCDEV KAHLLADMAH ISGLVAAKVI PSPFKHADIV TTTTHKTLRG ARSGLIFYRK GVKAVDPKTG REIPYTFEDR INFAVFPSLQ GGPHNHAIAA VAVALKQACT PMFREYSLQV LKNARAMADA LLERGYSLVS GGTDNHLVLV DLRPKGLDGA RAERVLELVS ITANKNTCPG DRSAITPGGL RLGAPALTSR QFREDDFRRV VDFIDEGVNI GLEVKSKTAK LQDFKSFLLK DSETSQRLAN LRQRVEQFAR AFPMPGFDEH
Mammalian serine hydroxymethyltransferase (SHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate in the cytoplasm (cSHMT, SHMT1) and mitochondria (mSHMT, SHMT2). cSHMT preferentially supplies one-carbon units for thymidylate biosynthesis, depletes methylenetetrahydrofolate pools for S-adenosylmethionine (SAM) synthesis by synthesizing serine, sequesters 5-methyltetrahydrofolate, and inhibits SAM synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: epididymis secretory sperm binding protein Li 51e; GLY A+; glycine auxotroph A, human complement for hamster; Glycine hydroxymethyltransferase; serine aldolase; serine hydroxymethylase; serine hydroxymethyltransferase 2 (mitochondrial); Serine hydroxymethyltransferase, mitochondrial; Serine methylase; SHMT; SHMT 2; threonine aldolase
Gene Aliases: GLYA; HEL-S-51e; SHMT; SHMT2
UniProt ID: (Human) P34897
Entrez Gene ID: (Human) 6472, (Rat) 299857
Molecular Function:
methyltransferase
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