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Immunogen sequence: PAVDEISDST STPATTRVTT NPSDSGKCPN VLNDPVNVRI NCIPEQFPTE GICAQRGCCW RPWNDSLIPW CFFVDNHGYN VQDMTTTSIG VEAKLNRIPS PTLFGNDINS VLFTTQNQTP NRFRFKITDP NNRRYEVPHQ YV
Highest antigen sequence identity to the following orthologs: Mouse - 61%, Rat - 63%.
This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha-glucosidase; oligosaccharide alpha-1,6-glucosidase; sucrase-isomaltase (alpha-glucosidase); Sucrase-isomaltase, intestinal
Gene Aliases: SI
UniProt ID: (Human) P14410
Entrez Gene ID: (Human) 6476
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