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Invitrogen
SIAH1 Polyclonal Antibody
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Application
FIGURE: 1 / 3
SIAH1 Antibody (PA5-102615) in IHC (P)
Immunohistochemistry analysis of SIAH1 in mouse brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with SIAH1 polyclonal antibody (Product # PA5-102615) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-102615
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SIAH1(Accession Q8IUQ4), corresponding to amino acid residues M1-N33.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2852012
Product Specific Information
Antibody detects endogenous levels of total SIAH1.
Target Information
This gene encodes a protein that is a member of the seven in absentia homolog family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase SIAH1; E3 ubiquitin-protein ligase SIAH1A; E3 ubiquitin-protein ligase SIAH1B; FLJ08065; h HUMSIAH; hSIAH1; mSiah-1a; RING-type E3 ubiquitin transferase SIAH1; RING-type E3 ubiquitin transferase SIAH1A; RING-type E3 ubiquitin transferase SIAH1B; seven in absentia 1A; Seven in absentia homolog 1; Seven in absentia homolog 1a; Seven in absentia homolog 1b; Siah-1; Siah-1a; Siah-1b
Gene Aliases: AA960570; AA982064; AI853500; HUMSIAH; SIAH; siah-1b; SIAH1; SIAH1A; Siah1b; Sinh1a; Sinh1b
UniProt ID: (Human) Q8IUQ4, (Rat) Q920M9, (Mouse) P61092, (Mouse) Q06985
Entrez Gene ID: (Human) 6477, (Rat) 140941, (Mouse) 20437, (Mouse) 20438
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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