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产品信息
PA3-200
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Horse,
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic Peptide: D(341) E A R T T E R E K P Q(352)
偶联物
Unconjugated
形式
Liquid
浓度
Conc. Not Determined
保存液
whole serum
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2188496
产品详细信息
PA3-200 detects human and rat SIRT2 and shows no cross-reactivity to other SIRT isoforms.
PA3-200 has been successfully used in Western blot and immunocytochemistry procedures. By Western blot, this antibody detects an ~48 kDa protein representing SIRT2 from SAOS2 cells. PA3-200 can be used for immunocytochemistry procedures.
PA3-200 immunizing peptide corresponds to amino acid residues 341-352 from the human SIRT2 protein. This sequence is completely conserved between human and rat.
靶标信息
The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair. It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells. SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise. SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 5E5 antigen; mSIR2L2; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; Regulatory protein SIR2 homolog 2; silent information regulator 2; silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2; SIR2-like protein 2; sir2-related protein type 2; sirtuin type 2; sirtuin-2
基因别名: 5730427M03Rik; SIR2; SIR2L; SIR2L2; SIRT2
UniProt ID: (Human) Q8IXJ6, (Mouse) Q8VDQ8
Entrez Gene ID: (Human) 22933, (Mouse) 64383, (Rat) 361532
