Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Reconstitution: 1 X 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Transport of folate compounds into mammalian cells can occur via receptor-mediated or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.
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Protein Aliases: Cyclic dinucleotide:anion antiporter SLC19A1; folate transporter 1; Folate:anion antiporter SLC19A1; FOLT; hSLC19A1; IFC-1; Intestinal folate carrier 1; intestinal folate carrier protein; Methotrexate carrier 1; methotrexate carrier 2; methotrexate carrier 5; methotrexate carrier 6; MTX-1; Placental folate transporter; Plasma membrane folate antiporter SLC19A1; Reduced folate carrier 1; Reduced folate carrier protein; Reduced folate transporter; Reduced folate transporter 1; RFC; RFC-1; RFC1; RFT-1; solute carrier family 19 (folate transporter), member 1; solute carrier family 19 (sodium/hydrogen exchanger), member 1; Solute carrier family 19 member 1; solute carrier family 19, member 1
Gene Aliases: AI323572; CHMD; FLOT1; FOLT; IFC1; MTX1; REFC; RFC; RFC-1; RFC1; SLC19A1
UniProt ID: (Human) P41440, (Mouse) P41438, (Rat) Q62866
Entrez Gene ID: (Human) 6573, (Mouse) 20509, (Rat) 29723
Molecular Function: transporter
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