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Product Details
PA5-106266
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SMAD1(Accession Q15797), corresponding to amino acid residues I436-S465.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2817648
Product Specific Information
Antibody detects endogenous levels of total Smad1/9.
Target Information
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BSP-1; Dwarfin-A; Dwf-A; JV4-1; MAD (mothers against decapentaplegic, Drosophila) homolog 1; MAD homolog 1; MAD homolog 9; MAD homolog1 (mothers against decapentaplegic, Drosophila); MAD, mothers against decapentaplegic homolog 1; Mad-related protein 1; Madh6; mMad1; Mothers against decapentaplegic homolog 1; Mothers against decapentaplegic homolog 9; Mothers against decapentaplegic, drosophila, homolog of, 9; mothers against DPP homolog 1; mothers against DPP homolog 9; Mothers-against-DPP-related 1; SMAD; SMAD 1; SMAD 9; SMAD family member 1; SMAD family member 9; SMAD, mothers against DPP homolog 1; SMAD, mothers against DPP homolog 9; Smad8; TGF-beta signaling protein 1; transforming growth factor-beta signaling protein 1; Transforming growth factor-beta-signaling protein 1
Gene Aliases: AI528653; BSP-1; BSP1; JV4-1; JV41; Mad1; MADH1; MADH6; Madh8; MADH9; MADR1; Mlp1; MusMLP; PPH2; SMAD1; SMAD8; SMAD8/9; SMAD8A; SMAD8B; SMAD9
UniProt ID: (Human) Q15797, (Human) O15198, (Mouse) P70340, (Rat) P97588, (Rat) O54835, (Mouse) Q9JIW5
Entrez Gene ID: (Human) 4086, (Human) 4093, (Mouse) 17125, (Rat) 25671, (Rat) 85435, (Mouse) 55994
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
receptor signaling protein activity
protein binding
protein kinase binding
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
identical protein binding
protein homodimerization activity
metal ion binding
protein heterodimerization activity
co-SMAD binding
I-SMAD binding
DNA binding
DNA-binding transcription factor
gene-specific transcriptional regulator
MAPK cascade
ureteric bud development
mesodermal cell fate commitment
osteoblast fate commitment
transcription from RNA polymerase II promoter
inflammatory response
signal transduction
transforming growth factor beta receptor signaling pathway
SMAD protein complex assembly
gamete generation
negative regulation of cell proliferation
embryonic pattern specification
positive regulation of gene expression
BMP signaling pathway
midbrain development
hindbrain development
primary miRNA processing
homeostatic process
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
cartilage development
cardiac muscle cell proliferation
bone development
SMAD protein signal transduction
positive regulation of cartilage development
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
transcription, DNA-templated
protein phosphorylation
cellular response to organic cyclic compound
cellular response to BMP stimulus
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
response to drug
positive regulation of cell differentiation
kidney development
response to organonitrogen compound
negative regulation of muscle cell apoptotic process
wound healing
positive regulation of dendrite morphogenesis
response to hypoxia
Mullerian duct regression
positive regulation of transcription, DNA-templated
Performance Guarantee
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