Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
14465-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SMC6 Fusion Protein Ag5812 (740-1091 aa encoded by BC039828)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.47 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TLEDEAQEN KSKMKMVEEH MEQQKENMEH LKSLKIEAEN KYDAIKFKIN QLSELADPLK DELNLADSEV DNQKRGKRHY EEKQKEHLDT LNKKKRELDM KEKELEEKMS QARQICPERI EVEKSASILD KEINRLRQKI QAEHASHGDR EEIMRQYQEA RETYLDLDSK VRTLKKFIKL LGEIMEHRFK TYQQFRRCLT LRCKLYFDNL LSQRAYCGKM NFDHKNETLS ISVQPGEGNK AAFNDMRALS GGERSFSTVC FILSLWSIAE SPFRCLDEFD VYMDMVNRRI AMDLILKMAD SQRFRQFILL TPQSMSSLPS SKLIRILRMS DPERGQTTLP FRPVTQEEDD DQR (740-1091 aa encoded by B C039828)
Target Information
Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: mSMC6; SMC protein 6; SMC6 structural maintenance of chromosomes 6-like 1; Structural maintenance of chromosomes protein 6
Gene Aliases: 2810489L22Rik; 3830418C19Rik; AA990493; AU018782; AW742439; hSMC6; Kiaa4103; mKIAA4103; SMC-6; SMC6; SMC6L1
UniProt ID: (Human) D6W518, (Mouse) Q924W5
Entrez Gene ID: (Human) 79677, (Rat) 313961, (Mouse) 67241
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support