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Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Lyso-PAF-PLC; Lyso-platelet-activating factor-phospholipase C; N-SMase; Neutral sphingomyelinase; neutral sphingomyelinase 1; NSMA; Sphingomyelin phosphodiesterase 2; sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
Gene Aliases: AW108287; ISC1; NSMASE; NSMASE1; SMPD2
UniProt ID: (Human) O60906, (Mouse) O70572
Entrez Gene ID: (Human) 6610, (Mouse) 20598
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