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            • Primary Antibodies ›
            • SOX2 Antibodies

            Invitrogen

            SOX2 Polyclonal Antibody

            Advanced Verification
            16 Published Figures
            30 References
            View all (93) SOX2 antibodies

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            Datasheet
            Protocols
            Questions & Answers
            Catalog # PA1-16968
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            Price (USD)
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            100 µL
             
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            Datasheet
            Protocols
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            Cite SOX2 Polyclonal Antibody

            • Antibody Testing Data (2)
            • Published Figures (16)
            • Advanced Verification (1)
            Application
            SOX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            Group 53 Created with Sketch.

            FIGURE: 1 / 19

            SOX2 Antibody (PA1-16968) in IHC (P)

            Immunohistochemical analysis of SOX2 in human uterus, endometrial glands. Samples were incubated in SOX2 polyclonal antibody (Product # PA1-16968).
            View Product

            SOX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            SOX2 Antibody in Western Blot (WB)
            SOX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            SOX2 Antibody in Immunocytochemistry (ICC/IF)
            SOX2 Antibody in Immunocytochemistry (ICC/IF)
            SOX2 Antibody in Immunocytochemistry (ICC/IF)
            SOX2 Antibody in Immunocytochemistry (ICC/IF)
            SOX2 Antibody in Immunocytochemistry (ICC/IF)
            SOX2 Antibody in Immunocytochemistry (ICC/IF)
            SOX2 Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF)
            SOX2 Antibody in Immunocytochemistry (ICC/IF)
            SOX2 Antibody in Immunocytochemistry (ICC/IF)
            SOX2 Antibody in Immunohistochemistry (IHC)
            SOX2 Antibody in Western Blot (WB)
            SOX2 Antibody in Western Blot (WB)
            SOX2 Antibody in Western Blot (WB)
            SOX2 Antibody in Flow Cytometry (Flow)
            SOX2 Antibody in Flow Cytometry (Flow)
            SOX2 Antibody

            Product Details

            PA1-16968

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            0.5 µg/mL
            View 4 publications 4 publications

            Immunohistochemistry (IHC)

            -
            View 4 publications 4 publications

            Immunohistochemistry (Paraffin) (IHC (P))

            1:125-1:250
            View 1 publication 1 publication

            Immunocytochemistry (ICC/IF)

            1:50-1:250
            View 16 publications 16 publications

            Flow Cytometry (Flow)

            1:100
            View 3 publications 3 publications

            Miscellaneous PubMed (Misc)

            -
            View 2 publications 2 publications
            Product Specifications

            Species Reactivity

            Dog, Human, Mouse, Sheep, Rat

            Published species

            Fish, Human, Mouse

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            Synthetic peptide made to the N-terminal region of human SOX2 protein (within residues 1-100). [Swiss-Prot# P48431]
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            1.0 mg/mL

            Purification

            Antigen affinity chromatography

            Storage buffer

            PBS

            Contains

            0.02% sodium azide

            Storage conditions

            -20°C, Avoid Freeze/Thaw Cycles

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2195781

            Product Specific Information

            The target sequence has 92% sequence homology with chicken, 86% sequence homology with xenopus, and 71% sequence homology with zebrafish.

            Suggested positive control: antigen standard for SOX2 (transient overexpression lysate), mouse brain lysate, mouse brain protein, uterual endometrial glands.

            Target Information

            SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            Related Products for

            Immunocytochemistry
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            Bioinformatics

            Protein Aliases: Delta EF2a; MCOPS3 (Microphthalmia Syndromic type 3); sex determining region Y-box 2; SOX 2; SRY (sex determining region Y) box 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY related HMG box 2; SRY-box 2; SRY-box containing gene 2; SRY-related HMG-box gene 2; Transcription factor SOX-2; transcription factor SOX2

            View more View less

            Gene Aliases: ANOP3; lcc; MCOPS3; RGD1565646; Sox-2; SOX2; ysb

            View more View less

            UniProt ID: (Human) P48431, (Sheep) P54231, (Mouse) P48432

            View more View less

            Entrez Gene ID: (Human) 6657, (Dog) 488092, (Sheep) 101110563, (Rat) 499593, (Mouse) 20674

            View more View less

            Function(s)

            transcription regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding miRNA binding sequence-specific DNA binding transcription regulatory region DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function chromatin binding transcription factor binding protein heterodimerization activity chromatin DNA binding HMG box transcription factor

            Process(es)

            negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation eye development endodermal cell fate specification chromatin organization regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cell cycle arrest response to wounding regulation of gene expression glial cell fate commitment pituitary gland development adenohypophysis development positive regulation of cell-cell adhesion forebrain development somatic stem cell population maintenance tissue regeneration regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade positive regulation of cell differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter inner ear development negative regulation of epithelial cell proliferation response to growth factor negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance cell fate specification positive regulation of neuroblast proliferation regulation of transcription from RNA polymerase II promoter sensory perception of sound response to organic substance stem cell population maintenance forebrain neuron differentiation cerebral cortex development negative regulation of Wnt signaling pathway male genitalia development positive regulation of epithelial cell differentiation olfactory placode formation response to retinoic acid inner ear morphogenesis tongue development cell fate commitment negative regulation of cell differentiation positive regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of Notch signaling pathway pigment biosynthetic process lung alveolus development embryonic organ development anatomical structure formation involved in morphogenesis neuron fate commitment diencephalon morphogenesis stem cell differentiation regulation of neurogenesis detection of mechanical stimulus involved in sensory perception of sound detection of mechanical stimulus involved in equilibrioception retina morphogenesis in camera-type eye lens induction in camera-type eye epithelial tube branching involved in lung morphogenesis transcription, DNA-templated multicellular organism development
            It has to be done as per old AB suggested Products section.
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