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Immunogen sequence: MKTPFGKTPG QRSRADAGHA GVSANMMKKR TSHKKHRSSV GPSKPVSQPR RNIVGCRIQH GWKEGNGPVT QWKGTVLDQV PVNPSLYLIK YDGFDCVYGL ELNKDERVSA LEVLPDRVAT SRISDAHLAD TMIGKAVEHM FETEDGSKDE WRGMVLARAP VMNTWFYITY EKDPVLYMYQ LLDDYKEGDL RIMPDSNDSP PAEREPGEVV DSLVGKQVEY AKEDGSKRTG MVIHQVEAKP SVYFIKFDDD FHIYVYDLVK TS; Positive Samples: MCF7, SW480, 293T, Jurkat, HeLa, HepG2, SH-SY5Y, Mouse brain; Cellular Location: Nucleus, nucleolus
SPIN1 (spindlin 1), also known as SPIN or ovarian cancer-related protein (OCR), is a 262 amino acid nuclear protein suggested to play a role in regulation of the cell-cycle during the transition from gamete to embryo. A member of the SPIN/STSY family, SPIN1 localizes to interphase nucleus and mitotic chromosomes, and is modified by phosphorylation in a cell-cycle-dependent fashion. A meiotic spindle-binding protein, SPIN1 overexpression has been shown to cause defects in mitotic spindles, thereby resulting in chromosome instability and potential tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 30000 Mr metaphase complex; Ovarian cancer-related protein; Spindlin-1; Spindlin1; SSEC P
Gene Aliases: OCR; SPIN; SPIN1; TDRD24
UniProt ID: (Human) Q9Y657, (Mouse) Q61142, (Rat) Q4V8J7
Entrez Gene ID: (Human) 10927, (Mouse) 20729, (Rat) 361217
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