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Invitrogen
SPIRE2 Polyclonal Antibody
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Product Details
PA5-61960
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SPIRE2. Recombinant protein control fragment (Product #RP-98593).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2647871
Product Specific Information
Immunogen sequence: HIPVYTLGFE SPQRVSAAKT APIQRRDIFQ SLQGPQWQSV EEAFPHIYSH GCVLKDVCSE CTSFVADVVR SSRKSVDVLN TTPRRSRQTQ SLYIPNTRTL D
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 81%.
Target Information
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein spire homolog 2; Spir-2; spire actin nucleation factor 2; spire family actin nucleation factor 2; spire homolog 2; spire-type actin nucleation factor 2
Gene Aliases: KIAA1832; Spir-2; SPIR2; SPIRE2
UniProt ID: (Human) Q8WWL2
Entrez Gene ID: (Human) 84501
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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