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Invitrogen
SPOCK1 Monoclonal Antibody (316801)
Application
FIGURE: 1 / 1
SPOCK1 Antibody (MA5-24039) in WB
International journal of molecular sciences 2020 -
Figure 5 Protein expression level for each paired sample. ( A ) Representative blots of GluR4, VIPR2, SPOCK1 and SLC6A3 protein expression in 10 CRC paired tissues samples. NaK ATPase was used as loading control. ( B ) Box plots of GluR4, VIPR2, SPOCK1 and SLC6A3 expression. Asterisks indicate statistically significant differences (* p value < 0.05, ** p value < 0.01, *** p value < 0.001). For the SPOCK1 ex... View More
Product Details
MA5-24039
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
316801
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Testican 1/SPOCK1 Arg22-Trp439
Conjugate
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608045
Product Specific Information
In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) Testican 2 or rhTestican 3 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
SPOCK1, also known as Testican-1, is a gene located on chromosome 5q31.2, encoding a member of the proteoglycan family characterized by containing multiple domains that facilitate interactions with other extracellular matrix proteins. SPOCK1 is primarily expressed in various tissues, including the brain and reproductive organs, where it plays crucial roles in modulating cell adhesion, migration, and matrix remodeling. Functionally, SPOCK1 contributes to the regulation of extracellular matrix composition, influencing processes such as tissue development and wound healing. In the context of cancer, SPOCK1 is often upregulated, promoting tumor progression and metastasis by enhancing cancer cell motility and invasiveness. Its involvement in these pathological mechanisms makes SPOCK1 a potential biomarker for cancer prognosis and a target for therapeutic intervention. Research continues to unravel SPOCK1's diverse biological activities and its impact on cellular architecture and disease progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ37170; Protein SPOCK; Testican-1
Gene Aliases: SPOCK; SPOCK1; TESTICAN; TIC1; TICN1
UniProt ID: (Human) Q08629
Entrez Gene ID: (Human) 6695
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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