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Product Details
11725-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SPOCK2 Fusion Protein Ag2313 (20-380 aa encoded by BC023558)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ALAEGDAKG LKEGETPGNF MEDEQWLSSI SQYSGKIKHW NRFRDEVEDD YIKSWEDNQQ GDEALDTTKD PCQKVKCSRH KVCIAQGYQR AMCISRKKLE HRIKQPTVKL HGNKDSICKP CHMAQLASVC GSDGHTYSSV CKLEQQACLS SKQLAVRCEG PCPCPTEQAA TSTADGKPET CTGQDLADLG DRLRDWFQLL HENSKQNGSA SSVAGPASGL DKSLGASCKD SIGWMFSKLD TSADLFLDQT ELAAINLDKY EVCIRPFFNS CDTYKDGRVS TAEWCFCFWR EKPPCLAELE RIQIQEAAKK KPGIFIPSCD EDGYYRKMQC DQSSGDCWCV DQLGLELTGT RTHGSPDCDD IV (20-380 aa encoded by BC023558)
Target Information
The SPOCK2 gene encodes the protein testican-2, a member of the SPARC (secreted protein acidic and rich in cysteine) family of extracellular matrix (ECM) proteins. SPOCK2 is involved in modulating the ECM environment, influencing cell-matrix interactions, tissue remodeling, and cellular communication. It plays a role in the regulation of proteolytic activity by inhibiting metalloproteinases, thereby contributing to the maintenance and integrity of the ECM. SPOCK2 is prominently expressed in the brain and testes, highlighting its involvement in neural development and reproductive biology. In neural tissues, it influences processes such as neuronal differentiation, synaptogenesis, and axonal guidance, which are critical for proper brain development and function. Dysregulation of SPOCK2 expression is associated with pathological conditions, including cancer, where it may impact tumor progression and metastasis through alterations in cell adhesion and migration. Research into SPOCK2's specific interactions and mechanisms continues, providing insights into its potential as a therapeutic target for managing ECM-related disorders and diseases involving abnormal cell-matrix interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ97039; KIAA0275CWCV; SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2; Testican-2
Gene Aliases: KIAA0275; SPOCK2; testican-2; TICN2; UNQ269/PRO306
UniProt ID: (Human) Q92563
Entrez Gene ID: (Human) 9806
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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