Product References
Advances on the early cellular events occurring upon exposure of human macrophages to aluminum oxyhydroxide adjuvant.
Scientific reports
Masson JD,Badran G,Domdom MA,Gherardi RK,Mograbi B,Authier FJ,Crépeaux G
PA5-20839 was used in Western Blotting to investigate the early in vitro response of primary human PBMCs obtained from healthy individuals to aluminum oxyhydroxide (the most commonly used adjuvant) and a whole vaccine, in terms of internalization, conventional and non-conventional autophagy pathways, inflammation, ROS production, and mitochondrial metabolism.
Thu Feb 23 00:00:00 EST 2023
HSPB8 counteracts tumor activity of BRAF- and NRAS-mutant melanoma cells by modulation of RAS-prenylation and autophagy.
Cell death & disease
Cristofani R,Piccolella M,Montagnani Marelli M,Tedesco B,Poletti A,Moretti RM
Published figure using SQSTM1 polyclonal antibody (Product # PA5-20839) in Western Blot
Fri Nov 18 00:00:00 EST 2022
HSPB8 counteracts tumor activity of BRAF- and NRAS-mutant melanoma cells by modulation of RAS-prenylation and autophagy.
Cell death & disease
Cristofani R,Piccolella M,Montagnani Marelli M,Tedesco B,Poletti A,Moretti RM
Published figure using SQSTM1 polyclonal antibody (Product # PA5-20839) in Western Blot
Fri Nov 18 00:00:00 EST 2022
NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ.
Nature communications
Huang J,Linares JF,Duran A,Xia W,Saltiel AR,Müller TD,Diaz-Meco MT,Moscat J
PA5-20839 was used in Western Blot to demonstrate that upon p62 inactivation, NBR1 represses the activity of PPARγ, establishing an unexplored p62/NBR1-mediated paradigm in adipocyte thermogenesis that is critical for the control of obesity.
Mon May 17 00:00:00 EDT 2021
NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ.
Nature communications
Huang J,Linares JF,Duran A,Xia W,Saltiel AR,Müller TD,Diaz-Meco MT,Moscat J
PA5-20839 was used in Western Blot to demonstrate that upon p62 inactivation, NBR1 represses the activity of PPARγ, establishing an unexplored p62/NBR1-mediated paradigm in adipocyte thermogenesis that is critical for the control of obesity.
Mon May 17 00:00:00 EDT 2021
Aggresome-Like Formation Promotes Resistance to Proteotoxicity in Cells from Long-Lived Species.
The journals of gerontology. Series A, Biological sciences and medical sciences
Sunchu B,Riordan RT,Yu Z,Almog I,Dimas-Munoz J,Drake AC,Perez VI
PA5-20839 was used in Immunocytochemistry to suggest that the resistance to proteotoxicity observed in long-lived species is not due to a lower level of protein aggregates but rather to enhanced handling of the protein aggregates through the formation of aggresome-like inclusions, a well-recognized protective mechanism against proteotoxicty.
Mon Jul 13 00:00:00 EDT 2020
Sinoporphyrin sodium is a promising sensitizer for photodynamic and sonodynamic therapy in glioma.
Oncology reports
An YW,Liu HQ,Zhou ZQ,Wang JC,Jiang GY,Li ZW,Wang F,Jin HT
PA5-20839 was used in Western Blotting to explore the antitumor effects of sinoporphyrin sodium (DVDMS)‚mediated photodynamic therapy (PDT) and sonodynamic therapy (SDT) in glioma, and to reveal the underlying mechanisms.
Thu Oct 01 00:00:00 EDT 2020
Long Term Pharmacological Perturbation of Autophagy in Mice: Are HCQ Injections a Relevant Choice?
Biomedicines
Masson JD,Blanchet B,Periou B,Authier FJ,Mograbi B,Gherardi RK,Crépeaux G
PA5-20839 was used in Western Blotting to develop a murine model of long-term systemic autophagy dysfunction, by the way of repeated injections of hydroxychloroquine (HCQ) in both juvenile and adult animals, while ensuring a limited impact on development, behaviour and motricity.
Sun Mar 01 00:00:00 EST 2020
Long Term Pharmacological Perturbation of Autophagy in Mice: Are HCQ Injections a Relevant Choice?
Biomedicines
Masson JD,Blanchet B,Periou B,Authier FJ,Mograbi B,Gherardi RK,Crépeaux G
PA5-20839 was used in Western Blotting to develop a murine model of long-term systemic autophagy dysfunction, by the way of repeated injections of hydroxychloroquine (HCQ) in both juvenile and adult animals, while ensuring a limited impact on development, behaviour and motricity.
Sun Mar 01 00:00:00 EST 2020
δ-Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells.
Cell proliferation
Fontana F,Moretti RM,Raimondi M,Marzagalli M,Beretta G,Procacci P,Sartori P,Montagnani Marelli M,Limonta P
Published figure using SQSTM1 polyclonal antibody (Product # PA5-20839) in Immunocytochemistry
Wed May 01 00:00:00 EDT 2019
δ-Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells.
Cell proliferation
Fontana F,Moretti RM,Raimondi M,Marzagalli M,Beretta G,Procacci P,Sartori P,Montagnani Marelli M,Limonta P
Published figure using SQSTM1 polyclonal antibody (Product # PA5-20839) in Immunocytochemistry
Wed May 01 00:00:00 EDT 2019
δ-Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells.
Cell proliferation
Fontana F,Moretti RM,Raimondi M,Marzagalli M,Beretta G,Procacci P,Sartori P,Montagnani Marelli M,Limonta P
Published figure using SQSTM1 polyclonal antibody (Product # PA5-20839) in Immunocytochemistry
Wed May 01 00:00:00 EDT 2019
δ-Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells.
Cell proliferation
Fontana F,Moretti RM,Raimondi M,Marzagalli M,Beretta G,Procacci P,Sartori P,Montagnani Marelli M,Limonta P
Published figure using SQSTM1 polyclonal antibody (Product # PA5-20839) in Immunocytochemistry
Wed May 01 00:00:00 EDT 2019
The Second Case of Saposin A Deficiency and Altered Autophagy.
JIMD reports
Kose M,Demir SA,Akinci G,Eraslan C,Yilmaz U,Ceylaner S,Yildirim ES,Seyrantepe V
PA5-20839 was used in Immunocytochemistry-immunoflourescence to report a case of Saposin A deficiency determined by a previously undescried homozygous variant in the saposin A domain of the PSAP gene.
Mon Sep 28 00:00:00 EDT 2020
Chick Embryo: A Preclinical Model for Understanding Ischemia-Reperfusion Mechanism.
Frontiers in pharmacology
Fauzia E,Barbhuyan TK,Shrivastava AK,Kumar M,Garg P,Khan MA,Robertson AAB,Raza SS
Published figure using SQSTM1 polyclonal antibody (Product # PA5-20839) in Western Blot
Thu Oct 01 00:00:00 EDT 2020
Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model.
Molecular brain
Mitsui S,Otomo A,Nozaki M,Ono S,Sato K,Shirakawa R,Adachi H,Aoki M,Sobue G,Shang HF,Hadano S
PA5-20839 was used in Immunohistochemistry to study disease models of amyotrophic lateral sclerosis SOD1 H46R mice to better understand progression of disease.
Tue May 29 00:00:00 EDT 2018
Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model.
Molecular brain
Mitsui S,Otomo A,Nozaki M,Ono S,Sato K,Shirakawa R,Adachi H,Aoki M,Sobue G,Shang HF,Hadano S
PA5-20839 was used in Immunohistochemistry to study disease models of amyotrophic lateral sclerosis SOD1 H46R mice to better understand progression of disease.
Tue May 29 00:00:00 EDT 2018
Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model.
Molecular brain
Mitsui S,Otomo A,Nozaki M,Ono S,Sato K,Shirakawa R,Adachi H,Aoki M,Sobue G,Shang HF,Hadano S
PA5-20839 was used in Immunohistochemistry to study disease models of amyotrophic lateral sclerosis SOD1 H46R mice to better understand progression of disease.
Tue May 29 00:00:00 EDT 2018
Dual role of autophagy on docetaxel-sensitivity in prostate cancer cells.
Cell death & disease
Cristofani R,Montagnani Marelli M,Cicardi ME,Fontana F,Marzagalli M,Limonta P,Poletti A,Moretti RM
Published figure using SQSTM1 polyclonal antibody (Product # PA5-20839) in Immunocytochemistry
Thu Aug 30 00:00:00 EDT 2018
Dual role of autophagy on docetaxel-sensitivity in prostate cancer cells.
Cell death & disease
Cristofani R,Montagnani Marelli M,Cicardi ME,Fontana F,Marzagalli M,Limonta P,Poletti A,Moretti RM
Published figure using SQSTM1 polyclonal antibody (Product # PA5-20839) in Immunocytochemistry
Thu Aug 30 00:00:00 EDT 2018
Ubiquitin-mediated regulation of the E3 ligase GP78 by MGRN1 in trans affects mitochondrial homeostasis.
Journal of cell science
Mukherjee R,Chakrabarti O
PA5-20839 was used in western blot to determine how mitochondrial homeostasis is affected by ubiquitin-mediated regulation of E3 ligase GP78 by MGRN1 in trans
Mon Feb 15 00:00:00 EST 2016
Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101.
Cell death & disease
Majumder P,Chakrabarti O
Published figure using SQSTM1 polyclonal antibody (Product # PA5-20839) in Western Blot
Thu Nov 05 00:00:00 EST 2015