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            • Primary Antibodies ›
            • SRC1 Antibodies

            Invitrogen

            SRC1 Polyclonal Antibody

            Advanced Verification
            2 Published Figures
            14 References
            View all (15) SRC1 antibodies
            Datasheet
            Protocols
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            Tech Support
            Catalog # PA1-840
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            Price (EUR)
            538,00
            100 µg
             
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            Datasheet
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            Cite SRC1 Polyclonal Antibody

            • Antibody Testing Data (4)
            • Published Figures (2)
            • Advanced Verification (1)
            Application
            SRC1 Antibody in Immunocytochemistry (ICC/IF)
            Group 53 Created with Sketch.

            FIGURE: 1 / 7

            SRC1 Antibody (PA1-840) in ICC/IF

            Immunofluorescence analysis of SRC1 was done on 70% confluent log phase A549 cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with SRC1 Rabbit Polyclonal Antibody (Product # PA1-840) at 1 µg/mL in 1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034) at a ... View More
            View Product

            SRC1 Antibody in Immunocytochemistry (ICC/IF)
            SRC1 Antibody in Immunocytochemistry (ICC/IF)
            SRC1 Antibody in Immunohistochemistry (IHC)
            SRC1 Antibody in Western Blot (WB)
            SRC1 Antibody in Western Blot, Immunoprecipitation (WB, IP)
            SRC1 Antibody in Western Blot (WB)
            SRC1 Antibody

            Product Details

            PA1-840

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1 µg/mL
            View 8 publications 8 publications

            Immunohistochemistry (IHC)

            -
            View 4 publications 4 publications

            Immunohistochemistry (Frozen) (IHC (F))

            1 µg/mL
            -

            Immunocytochemistry (ICC/IF)

            1-2 µg/mL
            -

            Immunoprecipitation (IP)

            -
            View 1 publication 1 publication

            ChIP assay (ChIP)

            -
            View 1 publication 1 publication
            Product Specifications

            Species Reactivity

            Avian, Human, Mouse

            Published species

            Amphibian, Avian, Chicken, Human, Mouse, Rat

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            Synthetic peptide corresponding to residues S(8) S D P A N P D S H K R K G S P C(24) of human SRC-1.
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            1 mg/mL

            Purification

            Antigen affinity chromatography

            Storage buffer

            PBS with 1mg/mL BSA

            Contains

            0.05% sodium azide

            Storage conditions

            -20°C, Avoid Freeze/Thaw Cycles

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2251288

            Product Specific Information

            PA1-840 detects steroid receptor coactivator-1 (SRC-1) from human, mouse, and japaneese quail tissues and cells.

            PA1-840 has been successfully used in Western blot, immunocytochemistry and immunohistochemistry procedures. By Western blot, this antibody detects an ~165 kDa protein representing SRC-1 and a smaller, unknown protein at ~40 kDa from HeLa cell lysate. Immunocytochemical staining of SRC-1 in HeLa cells with PA1-840 results in nuclear staining.

            The PA1-840 immunogen is a synthetic peptide corresponding to residues S(8) S D P A N P D S H K R K G S P C(24) of human SRC-1. This immunizing peptide (Cat. # PEP-044) is available for use in neutralization and control experiments.

            Target Information

            Clone 1135 recognizes SRC-1, steroid-receptor coactivator-1. SRC-1 is a member of a gene family that functions in the full transcriptional activation of the steroid hormone receptor superfamily and contains intrinsic histone acetyltransferase activity. SRC-1 has a molecular weight of 160 kDa and has a basic helix-loop-helix (bHLH)-PAS domain.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            Related Products for

            Bioinformatics

            Protein Aliases: ASV; bHLHe74; c-SRC; Class E basic helix-loop-helix protein 74; Hin-2 protein; mNRC-1; NCoA-1; Nuclear receptor coactivator 1; Nuclear receptor coactivator protein 1; p60-Src; PAX3/NCOA1 fusion protein; Protein Hin-2; Renal carcinoma antigen NY-REN-52; RIP160; SRC-1; SRC-1 (-Q); SRC-a/NCoA-1; Steroid receptor coactivator 1; steroid receptor coactivator-1

            View more View less

            Gene Aliases: bHLHe42; BHLHE74; F-SRC-1; KAT13A; NCOA1; RIP160; SRC-1; SRC1

            View more View less

            UniProt ID: (Human) Q15788, (Mouse) P70365

            View more View less

            Entrez Gene ID: (Human) 8648, (Mouse) 17977

            View more View less

            Function(s)

            RNA polymerase II regulatory region DNA binding RNA polymerase II transcription coactivator activity chromatin binding transcription coactivator activity histone acetyltransferase activity protein binding ligand-dependent nuclear receptor binding enzyme binding estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity protein complex binding progesterone receptor binding nuclear hormone receptor binding retinoid X receptor binding protein dimerization activity protein N-terminus binding androgen receptor binding DNA binding signal transducer activity transcription factor binding transferase activity transferase activity, transferring acyl groups retinoic acid receptor binding histone modifying enzyme

            Process(es)

            positive regulation of transcription from RNA polymerase II promoter by galactose regulation of thyroid hormone mediated signaling pathway transcription, DNA-templated lactation male gonad development bile acid and bile salt transport cerebellum development hippocampus development hypothalamus development cerebral cortex development androgen receptor signaling pathway intracellular receptor signaling pathway response to estradiol response to retinoic acid response to progesterone cellular response to hormone stimulus positive regulation of apoptotic process histone H4 acetylation cellular lipid metabolic process estrous cycle positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of female receptivity positive regulation of transcription from RNA polymerase II promoter male mating behavior labyrinthine layer morphogenesis cellular response to Thyroglobulin triiodothyronine regulation of cellular response to drug regulation of transcription, DNA-templated signal transduction regulation of nucleic acid-templated transcription regulation of RNA biosynthetic process
            It has to be done as per old AB suggested Products section.
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