Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 2
Positive Samples: Mouse heart, Mouse liver
Immunogen sequence: EDDEVGYSHP RYKDTPWCSP IKVKYGDVYC RAPQGGYYKT ALGTRCDIRC QKGYELHGSS LLICQSNKRW SDKVICKQKR CPTLAMPANG GFKCVDGAYF NSRCEYYCSP GYTLKGERTV TCMDNKAWSG RPASCVDMEP PRIKCPSVKE RIAEPNKLTV RVSWETPEGR DTADGILTDV ILKGLPPGSN FPEGDHKIQY TVYDRAENKG TCKFRVKVRV KRCGKLNAPE NGYMKCSSDG DNYGATCEFS CIGGYELQGS PARVCQSNLA WSGTEPTCAA M
SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DRS protein; Sushi-repeat-containing protein SRPX; sushi-repeat-containing protein, X chromosome; sushi-repeat-containing protein, X-chromosome
Gene Aliases: drs; drs-1; drs-2; mDRS-1; mDRS-2; Srpx
UniProt ID: (Mouse) Q9R0M3
Entrez Gene ID: (Mouse) 51795
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support