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Proteintech

SSRP1 Polyclonal Antibody

8 References

View all (18) SSRP1 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (6)

Application

SSRP1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

SSRP1 Antibody (15696-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 15696-1-AP (SSRP1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

SSRP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SSRP1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15696-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SSRP1 Fusion Protein Ag8318 (361-709 aa encoded by BC005116)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: YVHKPPVHI RFDEISFVNF ARGTTTTRSF DFEIETKQGT QYTFSSIERE EYGKLFDFVN AKKLNIKNRG LKEGMNPSYD EYADSDEDQH DAYLERMKEE GKIREENAND SSDDSGEETD ESFNPGEEEE DVAEEFDSNA SASSSSNEGD SDRDEKKRKQ LKKAKMAKDR KSRKKPVEVK KGKDPNAPKR PMSAYMLWLN ASREKIKSDH PGISITDLSK KAGEIWKGMS KEKKEEWDRK AEDARRDYEK AMKEYEGGRG ESSKRDKSKK KKKVKVKMEK KSTPSRGSSS KSSSRQLSES FKSKEFVSSD ESSSGENKSK KKRRRSEDSE EEELASTPPS SEDSASGSDE (361-709 aa encoded by BC005116)

Target Information

SPT16 and SSRP1 are found in all eurkaryotic cells and exists as part of an essential heterodimer complex. Together, SPT 16 and SSRP1 are a highly abundant nuclear complex that in mammals has been called FACT, or Facilitates Chromatin Transcription. FACT enhances the processivity of RNA polymerase II through nucleosomes. Evidence also points to a role for FACT in replication, possibly by enhancing DNA polymerase through nucleosomes as well.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Injectable Bacteria-Sensitive Hydrogel Promotes Repair of Infected Fractures via Sustained Release of miRNA Antagonist.

ACS applied materials & interfaces

Yu C,Chen L,Zhou W,Hu L,Xie X,Lin Z,Panayi AC,Zhan X,Tao R,Mi B,Liu G

Wed Aug 03 00:00:00 UTC 2022

TRPS1 drives heterochromatic origin refiring and cancer genome evolution.

Cell reports

Yang J,Liu X,Huang Y,He L,Zhang W,Ren J,Wang Y,Wu J,Wu X,Shan L,Yang X,Sun L,Liang J,Zhang Y,Shang Y

Tue Mar 09 00:00:00 UTC 2021

Chronic exercise training activates histone turnover in mouse skeletal muscle fibers.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Ohsawa I,Kawano F

Thu Apr 01 00:00:00 UTC 2021

SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p.

Journal of cellular and molecular medicine

Wu W,He K,Guo Q,Chen J,Zhang M,Huang K,Yang D,Wu L,Deng Y,Luo X,Yu H,Ding Q,Xiang G

Wed May 01 00:00:00 UTC 2019

SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p.

Journal of cellular and molecular medicine

Wu W,He K,Guo Q,Chen J,Zhang M,Huang K,Yang D,Wu L,Deng Y,Luo X,Yu H,Ding Q,Xiang G

Wed May 01 00:00:00 UTC 2019

SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.

International journal of medical sciences

Wang Q,Jia S,Jiao Y,Xu L,Wang D,Chen X,Hu X,Liang H,Wen N,Zhang S,Guo B,Zhang L

Thu Apr 30 00:00:00 UTC 2020

SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.

International journal of medical sciences

Wang Q,Jia S,Jiao Y,Xu L,Wang D,Chen X,Hu X,Liang H,Wen N,Zhang S,Guo B,Zhang L

Thu Apr 30 00:00:00 UTC 2020

Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.

Science translational medicine

Carter DR,Murray J,Cheung BB,Gamble L,Koach J,Tsang J,Sutton S,Kalla H,Syed S,Gifford AJ,Issaeva N,Biktasova A,Atmadibrata B,Sun Y,Sokolowski N,Ling D,Kim PY,Webber H,Clark A,Ruhle M,Liu B,Oberthuer A,Fischer M,Byrne J,Saletta F,Thwe le M,Purmal A,Haderski G,Burkhart C,Speleman F,De Preter K,Beckers A,Ziegler DS,Liu T,Gurova KV,Gudkov AV,Norris MD,Haber M,Marshall GM

Wed Nov 04 00:00:00 UTC 2015

Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.

Science translational medicine

Wed Nov 04 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Chromatin-specific transcription elongation factor 80 kDa subunit; cisplatin-DNA SSRP; facilitates chromatin remodeling 80 kDa subunit; Facilitates chromatin transcription complex 80 kDa subunit; Facilitates chromatin transcription complex subunit SSRP1; FACT 80 kDa subunit; FACT complex subunit SSRP1; FACTp80; high mobility group box; hSSRP1; Recombination signal sequence recognition protein 1; Structure-specific recognition protein 1; T160

Gene Aliases: C81323; Ciidbp; FACT; FACT80; Hmg1-rs1; Hmgi-rs3; Hmgox; SSRP1; T160

UniProt ID: (Human) Q08945, (Rat) Q04931, (Mouse) Q08943

Entrez Gene ID: (Human) 6749, (Rat) 81785, (Mouse) 20833

Function(s)

DNA binding chromatin binding protein binding poly(A) RNA binding molecular_function

Process(es)

DNA replication DNA repair regulation of transcription, DNA-templated transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter regulation of signal transduction by p53 class mediator chromatin remodeling transcription, DNA-templated biological_process cellular response to DNA damage stimulus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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