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Invitrogen
STIM1 Polyclonal Antibody
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Application
FIGURE: 1 / 7
STIM1 Antibody (PA5-82455) in ICC/IF
Immunofluorecent analysis of STIM1 in human cell line A549 using STIM1 Polyclonal Antibody (Product # PA5-82455). Staining shows localization to endoplasmic reticulum.
Product Details
PA5-82455
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human STIM1. Recombinant protein control fragment (Product #RP-90418).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2789613
Product Specific Information
Immunogen sequence: VHPGSLVEKL PDSPALAKKA LLALNHGLDK AHSLMELSPS APPGGSPHLD SSRSHSPSSP DPDTPSPVGD SRALQASRNT RIPHLAGKKA VAEEDNGSIG EETDSSPGRK KFPLKIFK
Target Information
STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: stim1 {ECO:0000312|RGD:1306831}; STIM1L; Stromal interaction molecule 1
Gene Aliases: D11S4896E; GOK; IMD10; Sim; STIM1; STRMK; TAM; TAM1
UniProt ID: (Human) Q13586, (Rat) P84903
Entrez Gene ID: (Human) 6786, (Rat) 361618
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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