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STX1A/STX1B Antibody (PA5-18411) in IHC (P)
Immunohistochemistry analysis of STX1A/STX1B in human brain, cortex. Samples were incubated with STX1A/STX1B polyclonal antibody (Product # PA5-18411) using a dilution of 5 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-18411
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (KDRTQELRTAKD) corresponding to the N-terminus amino acids of STX1ASTX1B (aa 2-13).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_10983680
Product Specific Information
This antibody is predicted to react with bovine, canine, human and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE domain, and an N-terminal regulatory domain. Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adipocyte; adiponectin; FP17469; HGNC:11433; Neuron-specific antigen HPC-1; syntaxin 1 a; syntaxin 1B1; syntaxin 1B2; syntaxin a/b; Syntaxin-1A; Syntaxin-1B
Gene Aliases: HPC-1; Stx1a; Stx1b; Stx1b1; Stx1b2; Stx1bl; Syn1b
UniProt ID: (Mouse) O35526, (Mouse) P61264
Entrez Gene ID: (Mouse) 20907, (Mouse) 56216
SNARE binding
glycoprotein binding
SNAP receptor activity
protein binding
myosin binding
calcium channel inhibitor activity
chloride channel inhibitor activity
kinase binding
protein domain specific binding
protein binding, bridging
myosin head/neck binding
ATP-dependent protein binding
ion channel binding
protein heterodimerization activity
protein N-terminus binding
calcium-dependent protein binding
protein kinase binding
SNARE protein
positive regulation of neurotransmitter secretion
transport
neurotransmitter transport
intracellular protein transport
exocytosis
response to gravity
positive regulation of norepinephrine secretion
regulation of synaptic vesicle priming
vesicle-mediated transport
calcium ion regulated exocytosis
regulation of exocytosis
synaptic vesicle fusion to presynaptic active zone membrane
secretion by cell
positive regulation of catecholamine secretion
positive regulation of exocytosis
positive regulation of calcium ion-dependent exocytosis
vesicle docking
positive regulation of excitatory postsynaptic potential
regulation of gene expression
protein transport
synaptic vesicle docking
spontaneous neurotransmitter secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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