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Proteintech

STXBP1 Monoclonal Antibody (1B5B3), CoraLite® Plus 488

View all (25) MUNC18 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (2)

Application

FIGURE: 1 / 2

STXBP1 Antibody (CL488-67137) in WB

Various lysates were subjected to SDS PAGE followed by western blot with CL488-67137 (STXBP1 antibody) at dilution of 1:2,000 incubated at room temperature for 1.5 hours.

STXBP1 Antibody in Flow Cytometry (Flow)

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Product Details

CL488-67137

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

Flow Cytometry (Flow)

0.80 µg/10^6 cells in a 100 µL suspension

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1B5B3

Immunogen

STXBP1 fusion protein Ag28605

Conjugate

CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.5% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: HELTFQAMS YDLLPIENDV YKYETSGIGE ARVKEVLLDE DDDLWIALRH KHIAEVSQEV TRSLKDFSSS KRMNTGEKTT MRDLSQMLKK MPQYQKELSK YSTHLHLAED CMKHYQGTVD KLCRVEQDLA MGTDAEGEKI KDPMRAIVPI LLDANVSTYD KIRIILLYIF LKNGITEENL NKLIQHAQIP PEDSEIITNM AHLGVPIVTD STLRRRSKPE RKERISEQTY QLSRWTPIIK DIMEDTIEDK LDTKHYPYIS TRSSASFSTT AVSARYGHWH KNKAPGEYRS GPRLIIFILG GVSLNEMRCA YEVTQANGKW EVLIGSTHIL TPQKLLDTLK KLNKTDEEIS S

Target Information

This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EIEE4; FLJ37475; hUNC18; MGC146482; minisatellite 10g detected by probe MMS10; munc-18c; MUNC18-1; N-Sec1; neuronal SEC1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; rbSec1; rop; RP11-56D16.3; Syntaxin-binding protein 1; UNC-18 homolog; unc-18-1; Unc-18A; Unc18-1

Gene Aliases: AI317162; AI326233; ANC18HA; MMS10-G; Ms10g; Munc-18a; MUNC18-1; N-sec1; NSEC1; NSEC1A; P67; Rb-sec1; RBSEC1; rbSec1A; rbSec1B; Sec1; STXBP1; Sxtbp1; UNC18; Unc18-1; UNC18A; Unc18h

UniProt ID: (Human) P61764, (Mouse) O08599, (Rat) P61765

Entrez Gene ID: (Human) 6812, (Mouse) 20910, (Rat) 25558

Function(s)

SNARE binding protein binding syntaxin-1 binding protein kinase binding protein domain specific binding syntaxin binding identical protein binding poly(A) RNA binding protein N-terminus binding membrane trafficking regulatory protein

Process(es)

platelet degranulation vesicle docking involved in exocytosis neurotransmitter secretion neuromuscular synaptic transmission axon target recognition regulation of synaptic vesicle priming glutamate secretion protein transport synaptic vesicle maturation regulation of synaptic vesicle fusion to presynaptic membrane negative regulation of synaptic transmission, GABAergic regulation of SNARE complex assembly negative regulation of neuron apoptotic process positive regulation of calcium ion-dependent exocytosis protein stabilization long term synaptic depression platelet aggregation protein localization to plasma membrane transport exocytosis vesicle-mediated transport synaptic vesicle fusion to presynaptic active zone membrane positive regulation of exocytosis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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