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Invitrogen
SUFU Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 1
SUFU Antibody (PA5-82360)
Relative expression in different tissues in IHC: Detection of differential expression levels of SUFU demonstrates antibody specificity. Immunohistochemical analysis of SUFU using anti-SUFU Polyclonal Antibody (Product #PA5-82360), shows significant staining of SUFU in testis and shows minimal or weak staining in liver tissues. The relative expression levels of SUFU within each tissue is shown using RNA-Seq... View More
Product Details
PA5-82360
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SUFU. Recombinant protein control fragment (Product #RP-89321).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Anitgen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2789519
Product Specific Information
Immunogen sequence: TEELHSAQQW NGQGILELLR TVPIAGGPWL ITDMRRGETI FEIDPHLQER VDKGIETDGS NLSGVSAKCA WDDLSRPPED DEDSRSICIG TQPRRLSGKD TEQIRETLRR GLEINSKPVL PPINPQRQNG LAHDRAPSRK DSLESDSSTA
Target Information
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OTTHUMP00000020377; OTTHUMP00000020378; OTTHUMP00000020379; RP11-47A8.1; SUFUH; Suppressor of fused homolog
Gene Aliases: PRO1280; SUFU; SUFUH; SUFUXL; UNQ650/PRO1280
UniProt ID: (Human) Q9UMX1
Entrez Gene ID: (Human) 51684
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
neural tube closure
heart looping
ventricular septum development
regulation of transcription, DNA-templated
proteolysis
signal transduction
multicellular organism development
smoothened signaling pathway involved in ventral spinal cord interneuron specification
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
aorta development
negative regulation of transcription factor import into nucleus
cytoplasmic sequestering of transcription factor
negative regulation of sequence-specific DNA binding transcription factor activity
skin development
negative regulation of osteoblast differentiation
negative regulation of smoothened signaling pathway
coronary vasculature development
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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