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Invitrogen
SUV39H2 Polyclonal Antibody
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Application
FIGURE: 1 / 3
SUV39H2 Antibody (PA5-11366) in IHC (P)
Immunohistochemistry analysis of SUV39H2 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with SUV39H2 polyclonal antibody (Product # PA5-11366) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = ... View More
Product Details
PA5-11366
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 360-390 amino acids from the C-terminal region of human SUV39H2
Conjugate
Unconjugated
Form
Liquid
Concentration
2 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2196733
Product Specific Information
This antibody is predicted to react with non-human primate based on sequence homology.
Target Information
The murine gene Suv39h2 encodes an H3 histone methyltransferase (HMTase) 59% identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ23414; H3 K9 HMTase 2; H3-K9-HMTase 2; Histone H3-K9 methyltransferase 2; Histone-lysine N-methyltransferase SUV39H2; KMT1; Lysine N-methyltransferase 1B; RP11-2K17.2; Su; Su(var)3-9 homolog 2; Suppressor of variegation 3-9 homolog 2
Gene Aliases: KMT1B; SUV39H2
UniProt ID: (Human) Q9H5I1
Entrez Gene ID: (Human) 79723, (Rat) 364785
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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