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产品信息
H00010492-M05
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
2E10
抗原
SYNCRIP (AAH32643, 1 a.a. approximately 527 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: MATEHVNGNG TEEPMDTTSA VIHSENFQTL LDAGLPQKVA EKLDEIYVAG LVAHSDLDER AIEALKEFNE DGALAVLQQF KDSDLSHVQN KSAFLCGVMK TYRQREKQGT KVADSSKGPD EAKIKALLER TGYTLDVTTG QRKYGGPPPD SVYSGQQPSV GTEIFVGKIP RDLFEDELVP LFEKAGPIWD LRLMMDPLTG LNRGYAFVTF CTKEAAQEAV KLYNNHEIRS GKHIGVCISV ANNRLFVGSI PKSKTKEQIL EEFSKVTEGL TDVILYHQPD DKKKNRGFCF LEYEDHKTAA QVKVLFVRNL ANTVTEEILE KAFSQFGKLE RVKKLKDYAF IHFDERDGTV KAMEEMNGKD LEGENIEIVF AKPPDQKRKE RKAQRQAAKN QMYDDYYYYG PPHMPPPTRG RGRGGRGGYG YPPDYYGYED YYDYYGYDYH NYRGGYEDPY YGYEDFQVGA RGRGGRGARG AAPSRGRGAA PPRGRAGYSQ RGGPGSARGV RGARGGAQQQ RGRGQGKGVE AGPDLLQ
靶标信息
Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; Heterogeneous nuclear ribonucleoprotein Q; hnRNP; hnRNP Q; NS1-associated protein 1; synaptotagmin binding, cytoplasmic RNA interacting protein; Synaptotagmin-binding, cytoplasmic RNA-interacting protein
基因别名: GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ; HNRPQ1; NSAP1; PP68; SYNCRIP
UniProt ID: (Human) O60506
Entrez Gene ID: (Human) 10492
