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OriGene
Somatostatin Receptor 3 (SSTR3) Monoclonal Antibody (OTI1A1)
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Product Details
CF812061
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI1A1
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human SSTR3:(NOVA)(NP_001042). The exact sequence is proprietary.
Conjugate
Unconjugated
Form
Lyophilized
Concentration
See Label
Purification
Protein A/G
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: somatostatin receptor; somatostatin receptor 28; somatostatin receptor subtype 3; Somatostatin receptor type 3; SS-3-R; SS3-R; SS3R; SSR-28
Gene Aliases: Smstr-3; Smstr28; Smstr3; SS-3-R; SS3-R; SS3R; SSR-28; sst3; SSTR; SSTR3
UniProt ID: (Human) P32745, (Mouse) P30935, (Rat) P30936
Entrez Gene ID: (Human) 6753, (Mouse) 20607, (Rat) 171044
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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