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Application
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Spinesin Antibody (PA5-47223) in IHC (F)
Immunohistochemical analysis of Spinesin in perfusion fixed frozen sections of mouse brain (cerebellum). Samples were incubated in Spinesin polyclonal antibody (Product # PA5-47223) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of ne... View More
Product Details
PA5-47223
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Spinesin Tyr61-Arg445
Conjugate
Unconjugated
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2605566
Product Specific Information
In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant human Spinesin is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Spinesin, also known as Serine protease 22 (PRSS22), is a gene located on chromosome 16p11.2 that encodes a trypsin-like serine protease predominantly expressed in the brain and airway tissues. This protease is part of the large family of serine proteases, characterized by their involvement in a variety of physiological processes, including digestion, immune response, and cellular remodeling. In the nervous system, Spinesin is implicated in synaptic function and plasticity, with potential roles in modulating neural connectivity and communication. It is also involved in processing extracellular matrix components, which can influence cell adhesion and migration, contributing to tissue remodeling and repair processes. Dysregulation of Spinesin expression or activity may impact neural development and has been associated with certain neurological disorders. Research into Spinesin continues to explore its specific functions in the nervous system and its potential therapeutic applications in neurobiology and regenerative medicine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC141886; MGC148044; Spinesin; Transmembrane protease serine 5
Gene Aliases: spinesin; Tmprss5
UniProt ID: (Mouse) Q9ER04
Entrez Gene ID: (Mouse) 80893
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