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            • Primary Antibodies ›
            • PPP1R9B Antibodies

            Bioss

            Spinophilin/Neurabin 2 Polyclonal Antibody

            View all (9) PPP1R9B antibodies
            Datasheet
            Protocols
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            Catalog # BS-12146R
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            Price (USD)
            444.00
            100 µL
             
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            Datasheet
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            Cite Spinophilin/Neurabin 2 Polyclonal Antibody

            • Antibody Testing Data (2)
            Application
            Spinophilin/Neurabin 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            Group 53 Created with Sketch.

            FIGURE: 1 / 2

            Spinophilin/Neurabin 2 Antibody (BS-12146R) in IHC (P)

            Formalin-fixed and paraffin embedded rat brain labeled with Anti-Spinophilin/Neurabin 2 Polyclonal Antibody, Unconjugated (bs-12146R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
            View Product

            Spinophilin/Neurabin 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            Spinophilin/Neurabin 2 Antibody in Western Blot (WB)

            Product Details

            BS-12146R

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1:1,000
            -

            Immunohistochemistry (Paraffin) (IHC (P))

            1:200
            -

            Immunohistochemistry (Frozen) (IHC (F))

            1:100-1:500
            -

            Immunocytochemistry (ICC/IF)

            1:100-1:500
            -

            ELISA (ELISA)

            1:500-1:1,000
            -
            Product Specifications

            Species Reactivity

            Human, Mouse, Rat

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            KLH conjugated synthetic peptide derived from human Spinophilin/Neurabin 2, amino acids 358-460.
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            1 mg/mL

            Purification

            Protein A

            Storage buffer

            0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

            Contains

            0.02% ProClin 300

            Storage conditions

            -20°C

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            Target Information

            Protein phosphatase 1 regulatory subunit 9B (PPP1R9B), also known as Neurabin II or spinophilin, is a gene located on chromosome 17q21.32 that encodes a regulatory protein predominantly expressed in the brain. PPP1R9B is involved in modulating the activity of protein phosphatase 1 (PP1), a crucial enzyme in cellular signaling pathways responsible for dephosphorylation of target proteins. Spinophilin functions by anchoring PP1 to specific subcellular locations, such as synaptic sites, thereby influencing synaptic plasticity, neurotransmission, and signal transduction. This protein is integral to the maintenance and modulation of excitatory synapses, playing a role in cognitive processes including learning and memory. Alterations in PPP1R9B expression or function have been associated with neuropsychiatric disorders and cancer, reflecting its importance in neuronal integrity and its potential role in tumorigenesis. Research into PPP1R9B continues to explore its therapeutic potential in neurological disorders and its utility in understanding phosphatase-related cellular processes.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            References (0)

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            Cite this product

            Bioinformatics

            Protein Aliases: neurabin 2; neurabin II; Neurabin-2; Neurabin-II; Neural tissue-specific F-actin-binding protein II; nuerabin 2; p130; PP1bp134; Protein phosphatase 1 regulatory subunit 9B; protein phosphatase 1, regulatory (inhibitor) subunit 9B; protein phosphatase 1, regulatory subunit 9B; protein phosphatase 1, regulatory subunit 9B, spinophilin; Spinophilin

            View more View less

            Gene Aliases: Neb2; PPP1R6; PPP1R9; PPP1R9B; SPINO; SPL; Spn

            View more View less

            UniProt ID: (Human) Q96SB3, (Rat) O35274, (Mouse) Q6R891

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            Entrez Gene ID: (Human) 84687, (Rat) 84686, (Mouse) 217124

            View more View less

            Function(s)

            protein phosphatase inhibitor activity protein binding protein phosphatase 1 binding actin filament binding actin binding protein kinase activity protein C-terminus binding kinase binding D2 dopamine receptor binding protein complex binding

            Process(es)

            regulation of protein phosphorylation actin filament organization dendrite development cell migration calcium-mediated signaling negative regulation of cell growth regulation of cell proliferation filopodium assembly modulation of synaptic transmission cellular response to morphine regulation of opioid receptor signaling pathway protein phosphorylation multicellular organism development nervous system development actin cytoskeleton organization cell differentiation negative regulation of phosphoprotein phosphatase activity cellular response to light stimulus positive regulation of establishment of protein localization to plasma membrane protein localization to actin cytoskeleton positive regulation of cellular protein localization regulation of cell growth by extracellular stimulus cell cycle arrest regulation of exit from mitosis RNA splicing neuron projection development negative regulation of catalytic activity
            It has to be done as per old AB suggested Products section.
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