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Invitrogen
TAB3 Polyclonal Antibody
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Application
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TAB3 Antibody (PA5-116885) in IHC (P)
Immunohistochemistry analysis of TAB3 in paraffin-embedded human liver cancer. Samples were incubated with TAB3 Polyclonal antibody (Product # PA5-116885) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Product Details
PA5-116885
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 390-480 of human TAB3 (NP_6900003)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.55 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2901515
Product Specific Information
Positive Samples: HepG2, Mouse spleen, Mouse heart, Rat testis
Immunogen sequence: QPSPRNQHSL YTATTPPSSS PSRGISSQPK PPFSVNPVYI TYTQPTGPSC TPSPSPRVIP NPTTVFKITV GRATTENLLN LVDQEERSAA P
Target Information
TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mitogen activated protein kinase kinase kinase 7 interacting protein 3; mitogen-activated protein kinase kinase kinase 7 interacting protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NF-kappa-B-activating protein 1; NFkB activating protein 1; TAB-3; TAK1-binding protein 3; TGF-beta activated kinase 1/MAP3K7 binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3
Gene Aliases: 4921526G09Rik; Kiaa4135; MAP3K7IP3; mKIAA4135; NAP1; TAB3
UniProt ID: (Human) Q8N5C8, (Mouse) Q571K4
Entrez Gene ID: (Human) 257397, (Rat) 317546, (Mouse) 66724
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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