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Application
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TAFA5 Antibody (MA5-24183) in IHC (P)
Immunohistochemical analysis of TAFA5 in immersion fixed paraffin-embedded sections of human cerebellum. Samples were incubated in TAFA5 monoclonal antibody (Product # MA5-24183) using a dilution of 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic. Tissue was stained using the Anti-Mouse HRP-... View More
Product Details
MA5-24183
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rat
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
463102
Immunogen
E. coli-derived recombinant human TAFA5/FAM19A5 Gln26-Ser125
Conjugate
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2607053
Product Specific Information
In direct ELISAs and Western blots, no cross-reactivity with recombinant human TAFA2, 3, or 4 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2. Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway. Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes. Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2. Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling . Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chemokine-like protein TAFA-5; family with sequence similarity 19 (chemokine (C-C motif)-like), member A5; TAFA protein 5
Gene Aliases: FAM19A5; QLLK5208; TAFA-5; TAFA5; UNQ5208; UNQ5208/PRO34524
UniProt ID: (Human) Q7Z5A7
Entrez Gene ID: (Human) 25817
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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