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TAX1BP1 Polyclonal Antibody

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Antibody Testing Data (11)

TAX1BP1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 11

TAX1BP1 Antibody (14424-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 14424-1-AP (TAX1BP1 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

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Product Details

14424-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunocytochemistry (ICC/IF)

1:10-1:100

View 4 publications 4 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TAX1BP1 Fusion Protein Ag5789 (454-789 aa encoded by BC050358)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KECQRLQKQ INKLSDQSAN NNNVFTKKTG NQQKVNDASV NTDPATSAST VDVKPSPSAA EADFDIVTKG QVCEMTKEIA DKTEKYNKCK QLLQDEKAKC NKYADELAKM ELKWKEQVKI AENVKLELAE VQDNYKELKR SLENPAERKM EGQNSQSPQC FKTCSEQNGY VLTLSNAQPV LQYGNPYASQ ETRDGADGAF YPDEIQRPPV RVPSWGLEDN VVCSQPARNF SRPDGLEDSE DSKEDENVPT APDPPSQHLR GHGTGFCFDS SFDVHKKCPL CELMFPPNYD QSKFEEHVES HWKVCPMCSE QFPPDYDQQV FERHVQTHFD QNVLNFD (454-789 aa encoded by BC050358 )

Target Information

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Copper-dependent autophagic degradation of GPX4 drives ferroptosis.

Autophagy

Xue Q,Yan D,Chen X,Li X,Kang R,Klionsky DJ,Kroemer G,Chen X,Tang D,Liu J

Sat Jul 01 00:00:00 EDT 2023

Profiling of purified autophagic vesicle degradome in the maturing and aging brain.

Neuron

Kallergi E,Siva Sankar D,Matera A,Kolaxi A,Paolicelli RC,Dengjel J,Nikoletopoulou V

Wed Aug 02 00:00:00 EDT 2023

Neuroprotective effect of alpha-kinase 1 knockdown against cerebral ischemia through inhibition of the NF-κB pathway and neuroinflammation.

International immunopharmacology

Li JY,Zheng ZX,Liu L,Du O,Yu NW,Zou Y,Seong SY,Du JR

Thu Dec 01 00:00:00 EST 2022

A detrimental role of NLRP6 in host iron metabolism during Salmonella infection.

Redox biology

Deng Q,Yang S,Sun L,Huang K,Dong K,Zhu Y,Cao Y,Li Y,Wu S,Huang R

Tue Feb 01 00:00:00 EST 2022

The long noncoding RNA LTCONS5539 up-regulates the TRAF6-mediated immune responses in miiuy croaker (Miichthys miiuy).

Fish & shellfish immunology

Pan J,Zheng W,Sun Y,Xu T

Fri Jul 01 00:00:00 EDT 2022

PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles.

Journal of nanobiotechnology

Fan Y,Cheng Z,Mao L,Xu G,Li N,Zhang M,Weng P,Zheng L,Dong X,Hu S,Wang B,Qin X,Jiang X,Chen C,Zhang J,Zou Z

Sat Mar 19 00:00:00 EDT 2022

Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity.

Autophagy

Hall BS,Dos Santos SJ,Hsieh LT,Manifava M,Ruf MT,Pluschke G,Ktistakis N,Simmonds RE

Fri Apr 01 00:00:00 EDT 2022

TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.

Autophagy

Wu W,Wang X,Sun Y,Berleth N,Deitersen J,Schlütermann D,Stuhldreier F,Wallot-Hieke N,José Mendiburo M,Cox J,Peter C,Bergmann AK,Stork B

Wed Dec 01 00:00:00 EST 2021

FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.

Scientific reports

Schlütermann D,Berleth N,Deitersen J,Wallot-Hieke N,Friesen O,Wu W,Stuhldreier F,Sun Y,Berning L,Friedrich A,Mendiburo MJ,Peter C,Wiek C,Hanenberg H,Stefanski A,Stühler K,Stork B

Mon Jul 05 00:00:00 EDT 2021

Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform.

Developmental cell

Zachari M,Gudmundsson SR,Li Z,Manifava M,Cugliandolo F,Shah R,Smith M,Stronge J,Karanasios E,Piunti C,Kishi-Itakura C,Vihinen H,Jokitalo E,Guan JL,Buss F,Smith AM,Walker SA,Eskelinen EL,Ktistakis NT

Mon Sep 09 00:00:00 EDT 2019

Tetrandrine Prevents Bone Loss in Ovariectomized Mice by Inhibiting RANKL-Induced Osteoclastogenesis.

Frontiers in pharmacology

Zhong Z,Qian Z,Zhang X,Chen F,Ni S,Kang Z,Zhang F,Li D,Yu B

Tue Sep 29 00:00:00 EDT 2020

A20/TNFAIP3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy.

Cancer research

Yang C,Zang W,Tang Z,Ji Y,Xu R,Yang Y,Luo A,Hu B,Zhang Z,Liu Z,Zheng X

Thu Feb 15 00:00:00 EST 2018

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

Cell

Zhong Z,Umemura A,Sanchez-Lopez E,Liang S,Shalapour S,Wong J,He F,Boassa D,Perkins G,Ali SR,McGeough MD,Ellisman MH,Seki E,Gustafsson AB,Hoffman HM,Diaz-Meco MT,Moscat J,Karin M

Thu Feb 25 00:00:00 EST 2016

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

Cell

Zhong Z,Umemura A,Sanchez-Lopez E,Liang S,Shalapour S,Wong J,He F,Boassa D,Perkins G,Ali SR,McGeough MD,Ellisman MH,Seki E,Gustafsson AB,Hoffman HM,Diaz-Meco MT,Moscat J,Karin M

Thu Feb 25 00:00:00 EST 2016

Bioinformatics

Protein Aliases: Tax1 (human T-cell leukemia virus type I) binding protein 1; Tax1-binding protein 1; Tax1-binding protein 1 homolog; TRAF6-binding protein; TRAF6-binding protein homolog

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Gene Aliases: 1200003J11Rik; 1700069J21Rik; AA930106; CALCOCO3; D6Ertd404e; D6Ertd772e; PRO0105; T6BP; TAX1BP1; TXBP151

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UniProt ID: (Human) Q86VP1, (Mouse) Q3UKC1

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Entrez Gene ID: (Human) 8887, (Mouse) 52440

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Function(s)

protein binding kinase binding metal ion binding ubiquitin binding

Process(es)

apoptotic process negative regulation of NF-kappaB transcription factor activity negative regulation of apoptotic process regulation of tumor necrosis factor-mediated signaling pathway negative regulation of type I interferon production

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TAX1BP1 Polyclonal Antibody

TAX1BP1 Antibody (14424-1-AP) in ICC/IF

Product Details

14424-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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